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Dnajc14 DnaJ heat shock protein family (Hsp40) member C14 [ Mus musculus (house mouse) ]

Gene ID: 74330, updated on 9-Dec-2024

Summary

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Official Symbol
Dnajc14provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C14provided by MGI
Primary source
MGI:MGI:1921580
See related
Ensembl:ENSMUSG00000025354 AllianceGenome:MGI:1921580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DNAJ; HDJ3; LIP6; DRIP78; 5730551F12Rik
Summary
Predicted to enable dopamine receptor binding activity. Predicted to be involved in protein transport. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human DNAJC14 (DnaJ heat shock protein family (Hsp40) member C14). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 8.4), CNS E11.5 (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc14 in Genome Data Viewer
Location:
10 D3; 10 77.16 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128641423..128655317)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128804904..128819448)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 2 Neighboring gene matrix metallopeptidase 19 Neighboring gene transmembrane protein 198b Neighboring gene STARR-positive B cell enhancer ABC_E1817 Neighboring gene STARR-positive B cell enhancer ABC_E74 Neighboring gene ORM1-like 2 (S. cerevisiae) Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene STARR-positive B cell enhancer ABC_E10662 Neighboring gene growth differentiation factor 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dopamine D1 receptor density in the mPFC responds to cognitive demands and receptor turnover contributes to general cognitive ability in mice. Wass C, et al. Sci Rep, 2018 Mar 14. PMID 29540721, Free PMC Article
  2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables dopamine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 14
Names
DnaJ (Hsp40) homolog, subfamily C, member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359824.1 → NP_001346753.1  dnaJ homolog subfamily C member 14

    Status: VALIDATED

    Source sequence(s)
    AC131081, AK017830, AK045445, AK082579, BE688094
    Consensus CDS
    CCDS24294.1
    UniProtKB/Swiss-Prot
    Q3TX73, Q8BUU3, Q921R4, Q9CYB7
    UniProtKB/TrEMBL
    Q8BLF3
    Related
    ENSMUSP00000151343.2, ENSMUST00000219508.2
    Conserved Domains (2) summary
    pfam00226
    Location:444 → 505
    DnaJ; DnaJ domain
    pfam14901
    Location:533 → 621
    Jiv90; Cleavage inducing molecular chaperone

  2. NM_001359825.1 → NP_001346754.1  dnaJ homolog subfamily C member 14

    Status: VALIDATED

    Source sequence(s)
    AC131081, AK045445, AK082579, BE688094
    Consensus CDS
    CCDS24294.1
    UniProtKB/Swiss-Prot
    Q3TX73, Q8BUU3, Q921R4, Q9CYB7
    UniProtKB/TrEMBL
    Q8BLF3
    Related
    ENSMUSP00000151530.2, ENSMUST00000217745.2
    Conserved Domains (2) summary
    pfam00226
    Location:444 → 505
    DnaJ; DnaJ domain
    pfam14901
    Location:533 → 621
    Jiv90; Cleavage inducing molecular chaperone

  3. NM_028873.5 → NP_083149.3  dnaJ homolog subfamily C member 14

    See identical proteins and their annotated locations for NP_083149.3

    Status: VALIDATED

    Source sequence(s)
    AK017830, AK082579, AK083878, BE688094
    Consensus CDS
    CCDS24294.1
    UniProtKB/Swiss-Prot
    Q3TX73, Q8BUU3, Q921R4, Q9CYB7
    UniProtKB/TrEMBL
    Q8BLF3
    Related
    ENSMUSP00000026410.2, ENSMUST00000026410.2
    Conserved Domains (2) summary
    pfam00226
    Location:444 → 505
    DnaJ; DnaJ domain
    pfam14901
    Location:533 → 621
    Jiv90; Cleavage inducing molecular chaperone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128641423..128655317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921R4.2 GenPept UniProtKB/Swiss-Prot:Q921R4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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