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Dpp8 dipeptidylpeptidase 8 [ Mus musculus (house mouse) ]

Gene ID: 74388, updated on 9-Dec-2024

Summary

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Official Symbol
Dpp8provided by MGI
Official Full Name
dipeptidylpeptidase 8provided by MGI
Primary source
MGI:MGI:1921638
See related
Ensembl:ENSMUSG00000032393 AllianceGenome:MGI:1921638
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DP8; DPP VIII; 2310004I03Rik; 4932434F09Rik
Summary
Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; immune system; limb mesenchyme; metanephros; and skin. Orthologous to human DPP8 (dipeptidyl peptidase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 15.6), cerebellum adult (RPKM 15.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dpp8 in Genome Data Viewer
Location:
9 C; 9 35.06 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64939688..64991785)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65032406..65084503)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene STARR-positive B cell enhancer ABC_E9330 Neighboring gene predicted gene, 39362 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24441 Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene immunoglobulin superfamily, DCC subclass, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation. Han R, et al. Sci Rep, 2015 Aug 5. PMID 26242871, Free PMC Article
  2. The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease. Buljevic S, et al. J Cell Biochem, 2018 Aug. PMID 29693275
  3. Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome. Okondo MC, et al. Cell Chem Biol, 2018 Mar 15. PMID 29396289, Free PMC Article
  4. The in vivo expression of dipeptidyl peptidases 8 and 9. Yu DM, et al. J Histochem Cytochem, 2009 Nov. PMID 19581630, Free PMC Article
  5. DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages. de Vasconcelos NM, et al. Life Sci Alliance, 2019 Feb. PMID 30718379, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
    Title: The effect of CD26-deficiency on dipeptidyl peptidase 8 and 9 expression profiles in a mouse model of Crohn's disease.
  2. Blocking the expression or activities of DPP8 and DPP9 attenuates PPARgamma2 induction during preadipocyte differentiation.
    Title: Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.
  3. Suggest roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis.
    Title: Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver.
  4. DP8 and DP9 tissue and cellular expression
    Title: The in vivo expression of dipeptidyl peptidases 8 and 9.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidyl-peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables dipeptidyl-peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dipeptidyl peptidase 8
Names
dipeptidyl peptidase VIII
NP_001388065.1
NP_083182.2
XP_006511580.1
XP_030100547.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401136.1 → NP_001388065.1  dipeptidyl peptidase 8

    Status: VALIDATED

    Source sequence(s)
    AC122463
    UniProtKB/Swiss-Prot
    Q80YA7, Q9D4G6
    Related
    ENSMUSP00000126065.2, ENSMUST00000167773.2

  2. NM_028906.3 → NP_083182.2  dipeptidyl peptidase 8

    See identical proteins and their annotated locations for NP_083182.2

    Status: VALIDATED

    Source sequence(s)
    AC122463
    Consensus CDS
    CCDS23285.1
    UniProtKB/Swiss-Prot
    Q80YA7, Q9D4G6
    Related
    ENSMUSP00000034960.7, ENSMUST00000034960.14
    Conserved Domains (2) summary
    pfam00326
    Location:680 → 885
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:169 → 589
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64939688..64991785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511517.5 → XP_006511580.1  dipeptidyl peptidase 8 isoform X2

    Conserved Domains (2) summary
    pfam00326
    Location:671 → 876
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:160 → 579
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. XM_030244687.2 → XP_030100547.1  dipeptidyl peptidase 8 isoform X3

    Conserved Domains (2) summary
    pfam00326
    Location:267 → 472
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:11 → 175
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

RNA

  1. XR_003948041.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YA7.1 GenPept UniProtKB/Swiss-Prot:Q80YA7

Gene LinkOut

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