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Rasgef1c RasGEF domain family, member 1C [ Mus musculus (house mouse) ]

Gene ID: 74563, updated on 2-Nov-2024

Summary

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Official Symbol
Rasgef1cprovided by MGI
Official Full Name
RasGEF domain family, member 1Cprovided by MGI
Primary source
MGI:MGI:1921813
See related
Ensembl:ENSMUSG00000020374 AllianceGenome:MGI:1921813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130006A14Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in olfactory cortex marginal layer; rest of cerebellum marginal layer; and ventral grey horn. Orthologous to human RASGEF1C (RasGEF domain family member 1C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 7.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Rasgef1c in Genome Data Viewer
Location:
11 B1.2- B1.3; 11 30.02 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49791996..49871050)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49901169..49980223)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29382 Neighboring gene predicted gene, 36507 Neighboring gene STARR-seq mESC enhancer starr_29384 Neighboring gene glutamine fructose-6-phosphate transaminase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5221 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene predicted gene, 53699 Neighboring gene ring finger protein 130 Neighboring gene microRNA 340 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-GEF domain-containing family member 1C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347462.1 → NP_001334391.1  ras-GEF domain-containing family member 1C isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK018593, AK039330, BX639019
    Consensus CDS
    CCDS83798.1
    UniProtKB/TrEMBL
    B1ATE5
    Related
    ENSMUSP00000065619.3, ENSMUST00000063444.3

  2. NM_029004.1 → NP_083280.1  ras-GEF domain-containing family member 1C isoform 2

    See identical proteins and their annotated locations for NP_083280.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK018593, AK047088, BX639019
    Consensus CDS
    CCDS24625.1
    UniProtKB/Swiss-Prot
    Q8BYJ7, Q9D300
    UniProtKB/TrEMBL
    B1ATE5
    Related
    ENSMUSP00000090829.6, ENSMUST00000093142.12
    Conserved Domains (2) summary
    cd06224
    Location:42 → 157
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:204 → 395
    RasGEF; RasGEF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    49791996..49871050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246404.1 → XP_030102264.1  ras-GEF domain-containing family member 1C isoform X2

    UniProtKB/Swiss-Prot
    Q8BYJ7, Q9D300
    UniProtKB/TrEMBL
    B1ATE5
    Conserved Domains (2) summary
    cd06224
    Location:42 → 157
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:204 → 395
    RasGEF; RasGEF domain

  2. XM_006534378.4 → XP_006534441.2  ras-GEF domain-containing family member 1C isoform X1

    UniProtKB/TrEMBL
    B1ATE5
    Conserved Domains (2) summary
    cd06224
    Location:42 → 157
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:204 → 395
    RasGEF; RasGEF domain

  3. XM_030246405.1 → XP_030102265.1  ras-GEF domain-containing family member 1C isoform X2

    UniProtKB/Swiss-Prot
    Q8BYJ7, Q9D300
    UniProtKB/TrEMBL
    B1ATE5
    Conserved Domains (2) summary
    cd06224
    Location:42 → 157
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:204 → 395
    RasGEF; RasGEF domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D300.1 GenPept UniProtKB/Swiss-Prot:Q9D300

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