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CORO2A coronin 2A [ Homo sapiens (human) ]

Gene ID: 7464, updated on 27-Nov-2024

Summary

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Official Symbol
CORO2Aprovided by HGNC
Official Full Name
coronin 2Aprovided by HGNC
Primary source
HGNC:HGNC:2255
See related
Ensembl:ENSG00000106789 MIM:602159; AllianceGenome:HGNC:2255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IR10; WDR2; CLIPINB
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 15.5), duodenum (RPKM 14.7) and 16 other tissues See more
Orthologs
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Genomic context

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See CORO2A in Genome Data Viewer
Location:
9q22.33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (98120975..98192637, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (110292922..110364586, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (100883257..100954919, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28686 Neighboring gene tripartite motif containing 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100833954-100834454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100836915-100837721 Neighboring gene N-acetylneuraminate synthase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100849215-100849889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100849890-100850563 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:100852934-100853493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28692 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:100921913-100922413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100924760-100925260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100933363-100934198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100935871-100936704 Neighboring gene Sharpr-MPRA regulatory region 7304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100953772-100954426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20117 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100957663-100958179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100960535-100961402 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:100961403-100962270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100963511-100964012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100964013-100964512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:100965136-100965636 Neighboring gene TBC1 domain family member 2 Neighboring gene Sharpr-MPRA regulatory region 378 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:100984952-100986151 Neighboring gene ADP ribosylation factor like GTPase 8B pseudogene Neighboring gene microRNA 6854

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. Rastetter RH, et al. BMC Cancer, 2015 Sep 15. PMID 26373535, Free PMC Article
  2. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. Zaphiropoulos PG, et al. DNA Cell Biol, 1996 Dec. PMID 8985118
  3. Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma. Kase-Kato I, et al. Int J Mol Sci, 2021 Nov 24. PMID 34884487, Free PMC Article
  4. Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A. Lim KH, et al. Oncotarget, 2016 Jun 7. PMID 27129179, Free PMC Article
  5. Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. Kim JC, et al. Int J Radiat Oncol Biol Phys, 2013 Jun 1. PMID 23490283

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma.
    Title: Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma.
  2. The regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis.
    Title: Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A.
  3. increased expression of coronin 2A is associated with the malignant phenotype of human colon carcinoma.
    Title: Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling.
  4. The candidate marker CORO2A rs1985859 and the putative marker FAM101A rs7955740 may be of value for the prediction of radiosensitivity to preoperative colorectal tumors.
    Title: Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Common variants in FOXP1 are associated with generalized vitiligo.
  6. Coronin 2A and cofilin regulate a subset of focal-adhesion-turnover events.
    Title: Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway.
  7. This protein is one of 10-12 associated proteins in the purified N-CoR complex.
    Title: Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686G19226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coronin-2A
Names
WD protein IR10
WD repeat-containing protein 2
WD-repeat protein 2
coronin, actin binding protein, 2A
coronin-like protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003389.3 → NP_003380.3  coronin-2A

    See identical proteins and their annotated locations for NP_003380.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains a distinct 5' UTR transcribed from an alternate exon, as compared to variant 2. Variants 1 and 2 encode the same protein and contain the same 3' UTR.
    Source sequence(s)
    AK292788, AL137073, BM822208, BM976925
    Consensus CDS
    CCDS6735.1
    UniProtKB/Swiss-Prot
    Q5TBR5, Q92828, Q92829, Q9BWS5
    UniProtKB/TrEMBL
    A8K9S3
    Related
    ENSP00000343746.5, ENST00000343933.9
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10 → 518
    WD40_4; Type of WD40 repeat

  2. NM_052820.4 → NP_438171.1  coronin-2A

    See identical proteins and their annotated locations for NP_438171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR transcribed from an alternate exon, as compared to variant 1. Variants 1 and 2 encode the same protein and contain the same 3' UTR.
    Source sequence(s)
    AK292788, AL137073, BC011690, BM976925
    Consensus CDS
    CCDS6735.1
    UniProtKB/Swiss-Prot
    Q5TBR5, Q92828, Q92829, Q9BWS5
    UniProtKB/TrEMBL
    A8K9S3
    Related
    ENSP00000364218.4, ENST00000375077.5
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10 → 518
    WD40_4; Type of WD40 repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    98120975..98192637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518986.4 → XP_011517288.1  coronin-2A isoform X1

    See identical proteins and their annotated locations for XP_011517288.1

    UniProtKB/Swiss-Prot
    Q5TBR5, Q92828, Q92829, Q9BWS5
    UniProtKB/TrEMBL
    A8K9S3
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl25676
    Location:10 → 518
    WD40_4; Type of WD40 repeat

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    110292922..110364586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363755.1 → XP_054219730.1  coronin-2A isoform X1

    UniProtKB/Swiss-Prot
    Q5TBR5, Q92828, Q92829, Q9BWS5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92828.2 GenPept UniProtKB/Swiss-Prot:Q92828

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