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Lrrc74b leucine rich repeat containing 74B [ Mus musculus (house mouse) ]

Gene ID: 74685, updated on 9-Dec-2024

Summary

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Official Symbol
Lrrc74bprovided by MGI
Official Full Name
leucine rich repeat containing 74Bprovided by MGI
Primary source
MGI:MGI:1921935
See related
Ensembl:ENSMUSG00000022759 AllianceGenome:MGI:1921935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mCG12354; mCP17390; 4930451C15Rik
Summary
Orthologous to human LRRC74B (leucine rich repeat containing 74B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in ovary adult (RPKM 2.4), genital fat pad adult (RPKM 1.9) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrc74b in Genome Data Viewer
Location:
16 A3; 16 10.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17362329..17379159, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17544465..17561328, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine-zipper-like transcriptional regulator, 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17531169-17531278 Neighboring gene THAP domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E10890 Neighboring gene STARR-seq mESC enhancer starr_40257 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 6 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Risk of meningomyelocele mediated by the common 22q11.2 deletion. Vong KI, et al. Science, 2024 May 3. PMID 38696583
  2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 74B
Names
leucine-rich repeat-containing protein LOC400891 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145435.1 → NP_001138907.1  leucine-rich repeat-containing protein 74B isoform 2

    See identical proteins and their annotated locations for NP_001138907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113006, AK161226, BB634732
    Consensus CDS
    CCDS49777.1
    UniProtKB/Swiss-Prot
    Q14BP6
    Related
    ENSMUSP00000023442.7, ENSMUST00000023442.13
    Conserved Domains (3) summary
    cd00116
    Location:56 → 340
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:159 → 190
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:189 → 257
    LRR_8; Leucine rich repeat

  2. NM_029053.3 → NP_083329.2  leucine-rich repeat-containing protein 74B isoform 1

    See identical proteins and their annotated locations for NP_083329.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (1).
    Source sequence(s)
    AC113006, AK161226, BB634732, BC115678
    Consensus CDS
    CCDS28006.2
    UniProtKB/Swiss-Prot
    Q14BP6, Q3UPS2, Q8BYL7
    Related
    ENSMUSP00000097699.4, ENSMUST00000100123.10
    Conserved Domains (3) summary
    sd00031
    Location:303 → 315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:159 → 190
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:56 → 353
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17362329..17379159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522677.4 → XP_006522740.1  leucine-rich repeat-containing protein 74B isoform X2

    Related
    ENSMUSP00000155867.2, ENSMUST00000232637.2
    Conserved Domains (3) summary
    sd00031
    Location:303 → 315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:159 → 190
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:56 → 339
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. XM_011246037.3 → XP_011244339.1  leucine-rich repeat-containing protein 74B isoform X1

    See identical proteins and their annotated locations for XP_011244339.1

    Conserved Domains (3) summary
    sd00031
    Location:303 → 315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:159 → 190
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:56 → 339
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_036160173.1 → XP_036016066.1  leucine-rich repeat-containing protein 74B isoform X2

    Conserved Domains (3) summary
    sd00031
    Location:303 → 315
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:159 → 190
    LRR_RI; leucine-rich repeat [structural motif]
    cl39015
    Location:56 → 339
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RNA

  1. XR_875856.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14BP6.1 GenPept UniProtKB/Swiss-Prot:Q14BP6

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