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Odad2 outer dynein arm docking complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 74934, updated on 28-Oct-2024

Summary

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Official Symbol
Odad2provided by MGI
Official Full Name
outer dynein arm docking complex subunit 2provided by MGI
Primary source
MGI:MGI:1922184
See related
Ensembl:ENSMUSG00000061802 AllianceGenome:MGI:1922184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Armc4; b2b643Clo; b2b227.1Clo; 4930463I21Rik
Summary
Acts upstream of or within several processes, including determination of left/right symmetry; outer dynein arm assembly; and ventricular system development. Predicted to be located in axoneme and ciliary base. Is expressed in node. Used to study Kartagener syndrome; primary ciliary dyskinesia 23; and visceral heterotaxy. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 23. Orthologous to human ODAD2 (outer dynein arm docking complex subunit 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 5.0) and ovary adult (RPKM 0.3) See more
Orthologs
human all
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Genomic context

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See Odad2 in Genome Data Viewer
Location:
18 A1; 18 4.53 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (7088233..7298272, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (7088233..7298273, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene mohawk homeobox Neighboring gene predicted gene, 46633 Neighboring gene STARR-seq mESC enhancer starr_43731 Neighboring gene predicted gene 10350 Neighboring gene predicted gene, 18581 Neighboring gene STARR-seq mESC enhancer starr_43732 Neighboring gene predicted gene, 34979 Neighboring gene STARR-seq mESC enhancer starr_43733 Neighboring gene membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) Neighboring gene STARR-seq mESC enhancer starr_43734 Neighboring gene STARR-positive B cell enhancer mm9_chr18:7497579-7497879 Neighboring gene STARR-seq mESC enhancer starr_43735 Neighboring gene MAD2 mitotic arrest deficient-like 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Lonergan KM, et al. Am J Respir Cell Mol Biol, 2006 Dec. PMID 16809635
  2. CFAP61 is required for sperm flagellum formation and male fertility in human and mouse. Liu S, et al. Development, 2021 Dec 1. PMID 34792097
  3. ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. Hjeij R, et al. Am J Hum Genet, 2013 Aug 8. PMID 23849778, Free PMC Article
  4. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  5. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cilium movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within outer dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium beat frequency IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cilium beat frequency ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
outer dynein arm-docking complex subunit 2
Names
armadillo repeat containing 4
armadillo repeat-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357492.1 → NP_001344421.1  outer dynein arm-docking complex subunit 2

    Status: VALIDATED

    Source sequence(s)
    BB573298, BB679543, BC158097
    Consensus CDS
    CCDS37729.1
    UniProtKB/Swiss-Prot
    B2RY50, Q9CUL6
    Related
    ENSMUSP00000157197.2, ENSMUST00000234788.2
    Conserved Domains (4) summary
    PLN03200
    Location:618 → 855
    PLN03200; cellulose synthase-interactive protein; Provisional
    COG5064
    Location:750 → 1035
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:919 → 947
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:876 → 901
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    7088233..7298272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526313.5 → XP_006526376.1  outer dynein arm-docking complex subunit 2 isoform X3

    Conserved Domains (4) summary
    PLN03200
    Location:473 → 710
    PLN03200; cellulose synthase-interactive protein; Provisional
    COG5064
    Location:605 → 890
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:774 → 802
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:731 → 756
    ARM; armadillo repeat [structural motif]

  2. XM_036161300.1 → XP_036017193.1  outer dynein arm-docking complex subunit 2 isoform X2

    Conserved Domains (4) summary
    PLN03200
    Location:494 → 731
    PLN03200; cellulose synthase-interactive protein; Provisional
    COG5064
    Location:626 → 911
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:795 → 823
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:752 → 777
    ARM; armadillo repeat [structural motif]

  3. XM_030250622.1 → XP_030106482.1  outer dynein arm-docking complex subunit 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RY50, Q9CUL6
    Related
    ENSMUSP00000080028.5, ENSMUST00000081275.5
    Conserved Domains (4) summary
    PLN03200
    Location:618 → 855
    PLN03200; cellulose synthase-interactive protein; Provisional
    COG5064
    Location:750 → 1035
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:919 → 947
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:876 → 901
    ARM; armadillo repeat [structural motif]

  4. XM_011247017.1 → XP_011245319.1  outer dynein arm-docking complex subunit 2 isoform X5

    Conserved Domains (3) summary
    PLN03200
    Location:167 → 404
    PLN03200; cellulose synthase-interactive protein; Provisional
    COG5064
    Location:299 → 584
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:459 → 488
    ARM; armadillo repeat [structural motif]

  5. XM_011247016.1 → XP_011245318.1  outer dynein arm-docking complex subunit 2 isoform X4

    Conserved Domains (3) summary
    PLN03200
    Location:312 → 549
    PLN03200; cellulose synthase-interactive protein; Provisional
    COG5064
    Location:444 → 729
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:604 → 633
    ARM; armadillo repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081393.1: Suppressed sequence

    Description
    NM_001081393.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RY50.1 GenPept UniProtKB/Swiss-Prot:B2RY50

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