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c6ast1 six-cysteine containing astacin protease 1 [ Danio rerio (zebrafish) ]

Gene ID: 751088, updated on 2-Nov-2024

Summary

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Official Symbol
c6ast1provided by ZNC
Official Full Name
six-cysteine containing astacin protease 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070621-1
See related
Ensembl:ENSDARG00000069216 AllianceGenome:ZFIN:ZDB-GENE-070621-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zc6ast1
Summary
Predicted to enable metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See c6ast1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (38661870..38664947, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (38390612..38393689, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene six-cysteine containing astacin protease 3 Neighboring gene nephrosin Neighboring gene mitochondrial carrier homolog 2 Neighboring gene proteasome 26S subunit, ATPase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of teleostean hatching enzyme genes and their paralogous genes. Kawaguchi M, et al. Dev Genes Evol, 2006 Dec. PMID 17016731
  2. The seahorse genome and the evolution of its specialized morphology. Lin Q, et al. Nature, 2016 Dec 14. PMID 27974754, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
six-cysteine containing astacin protease 1
Names
astacin like metallo-protease
NP_001036784.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043319.1 → NP_001036784.1  six-cysteine containing astacin protease 1 precursor

    See identical proteins and their annotated locations for NP_001036784.1

    Status: PROVISIONAL

    Source sequence(s)
    AB256952
    UniProtKB/TrEMBL
    A0A8M1N8X0, Q14TH1
    Related
    ENSDARP00000091319.4, ENSDART00000100546.6
    Conserved Domains (2) summary
    cd04283
    Location:77 → 257
    ZnMc_hatching_enzyme; Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related ...
    pfam01400
    Location:71 → 259
    Astacin; Astacin (Peptidase family M12A)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    38661870..38664947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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