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Cep43 centrosomal protein 43 [ Mus musculus (house mouse) ]

Gene ID: 75296, updated on 9-Dec-2024

Summary

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Official Symbol
Cep43provided by MGI
Official Full Name
centrosomal protein 43provided by MGI
Primary source
MGI:MGI:1922546
See related
Ensembl:ENSMUSG00000069135 AllianceGenome:MGI:1922546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FOP; Fgfr1op; 4930553O10Rik
Summary
Predicted to enable protein homodimerization activity; protein kinase binding activity; and protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of protein kinase activity; positive regulation of cell growth; and positive regulation of cell migration. Predicted to be located in centriole; nucleus; and perinuclear region of cytoplasm. Predicted to be active in centrosome. Is expressed in several structures, including intestine; lung; renal tubule; spinal ganglion; and vibrissa follicle. Orthologous to human CEP43 (centrosomal protein 43). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis adult (RPKM 11.1), CNS E11.5 (RPKM 7.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Cep43 in Genome Data Viewer
Location:
17 A1; 17 4.88 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (8383976..8415309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (8165143..8196477)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41523 Neighboring gene STARR-seq mESC enhancer starr_41760 Neighboring gene ribonuclease T2A Neighboring gene STARR-positive B cell enhancer mm9_chr17:8358162-8358463 Neighboring gene STARR-positive B cell enhancer ABC_E7487 Neighboring gene STARR-seq mESC enhancer starr_41762 Neighboring gene C-C motif chemokine receptor 6 Neighboring gene predicted gene, 33799 Neighboring gene predicted gene 8465

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutation of FOP/FGFR1OP in mice recapitulates human short rib-polydactyly ciliopathy. Cabaud O, et al. Hum Mol Genet, 2018 Oct 1. PMID 29982567
  2. The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells. Trsan T, et al. Dev Cell, 2024 Sep 23. PMID 38942017,
  3. FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. Guasch G, et al. Blood, 2004 Jan 1. PMID 12969958
  4. The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Bauer H, et al. Nat Genet, 2005 Sep. PMID 16116428
  5. A ciliopathy complex builds distal appendages to initiate ciliogenesis. Kumar D, et al. J Cell Biol, 2021 Sep 6. PMID 34241634, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90966, MGC117820

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule anchoring IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein 43
Names
Fgfr1 oncogene partner

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197046.1 → NP_001183975.1  centrosomal protein 43 isoform 1

    See identical proteins and their annotated locations for NP_001183975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB615739, BC108331
    Consensus CDS
    CCDS57045.1
    UniProtKB/Swiss-Prot
    Q32P17, Q66JX5, Q8BH91
    Related
    ENSMUSP00000095030.4, ENSMUST00000097419.10
    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

  2. NM_201230.5 → NP_957682.1  centrosomal protein 43 isoform 2

    See identical proteins and their annotated locations for NP_957682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK016110, AK050389, BC108331
    Consensus CDS
    CCDS28380.1
    UniProtKB/Swiss-Prot
    Q66JX5
    Related
    ENSMUSP00000024636.9, ENSMUST00000024636.15
    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    8383976..8415309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250124.2 → XP_030105984.1  centrosomal protein 43 isoform X1

    UniProtKB/Swiss-Prot
    Q32P17, Q66JX5, Q8BH91
    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

  2. XM_036160821.1 → XP_036016714.1  centrosomal protein 43 isoform X4

  3. XM_006523357.3 → XP_006523420.1  centrosomal protein 43 isoform X2

    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

  4. XM_030250125.1 → XP_030105985.1  centrosomal protein 43 isoform X3

    Conserved Domains (1) summary
    pfam09398
    Location:54 → 134
    FOP_dimer; FOP N terminal dimerization domain

RNA

  1. XR_004939597.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66JX5.1 GenPept UniProtKB/Swiss-Prot:Q66JX5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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