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ZNF3 zinc finger protein 3 [ Homo sapiens (human) ]

Gene ID: 7551, updated on 10-Dec-2024

Summary

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Official Symbol
ZNF3provided by HGNC
Official Full Name
zinc finger protein 3provided by HGNC
Primary source
HGNC:HGNC:13089
See related
Ensembl:ENSG00000166526 MIM:194510; AllianceGenome:HGNC:13089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A8-51; HF.12; KOX25; PP838; Zfp113
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in endometrium (RPKM 7.6), thyroid (RPKM 6.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF3 in Genome Data Viewer
Location:
7q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100063837..100082577, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101303346..101322424, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99661460..99680200, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26332 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99601306-99601806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99604826-99605326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99605327-99605827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99607545-99608044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18412 Neighboring gene zinc finger with KRAB and SCAN domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99634953-99635454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99635455-99635954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99647299-99647918 Neighboring gene zinc finger and SCAN domain containing 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26333 Neighboring gene Sharpr-MPRA regulatory region 7718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26334 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99679591-99680572 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:99684712-99685405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18414 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:99686990-99688189 Neighboring gene Sharpr-MPRA regulatory region 1952 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 25 Neighboring gene minichromosome maintenance complex component 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer. Du L, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Dec 25. PMID 36789689, Free PMC Article
  2. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. Pannuti A, et al. Nucleic Acids Res, 1988 May 25. PMID 3380682, Free PMC Article
  3. Members of the zinc finger protein gene family sharing a conserved N-terminal module. Rosati M, et al. Nucleic Acids Res, 1991 Oct 25. PMID 1945843, Free PMC Article
  4. Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1. Dumoulin B, et al. Biochim Biophys Acta Gen Subj, 2020 Nov. PMID 32645484
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer.
    Title: ZNF3 regulates proliferation, migration and invasion through MMP1 and TWIST in colorectal cancer.
  2. ZNF3 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
    Title: The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in leukocyte activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 3
Names
C2-H2 type zinc finger protein
zinc finger protein HF.12
zinc finger protein HZF3.1
zinc finger protein KOX25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278284.2 → NP_001265213.1  zinc finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001265213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 2. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
    Source sequence(s)
    AC073842, BC041695, CA439866
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001278287.2 → NP_001265216.1  zinc finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001265216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
    Source sequence(s)
    AC073842, BC041695, BQ071498, CA439866
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001278290.2 → NP_001265219.1  zinc finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001265219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
    Source sequence(s)
    BC041695, CA439866, HY096067
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Related
    ENSP00000415358.1, ENST00000424697.5
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001278291.2 → NP_001265220.1  zinc finger protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001265220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks the exon containing the translation start site, and initiates translation at an alternate start codon compared to variant 3. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 6, 7, 13, 19, and 20 all encode the same isoform (3).
    Source sequence(s)
    BC041695, CA439866, DA443888
    Consensus CDS
    CCDS94152.1
    UniProtKB/TrEMBL
    C9JIW8, Q86U76
    Related
    ENSP00000416088.2, ENST00000412947.6
    Conserved Domains (4) summary
    COG5048
    Location:139 → 317
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250 → 270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 55
    KRAB; KRAB box
    pfam13465
    Location:318 → 343
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001278292.2 → NP_001265221.1  zinc finger protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001265221.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks the exon containing the translation start site and initiates translation at an alternate start codon compared to variant 3. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 6, 7, 13, 19, and 20 all encode the same isoform (3).
    Source sequence(s)
    BC041695, CA439866, DA623743
    Consensus CDS
    CCDS94152.1
    UniProtKB/TrEMBL
    C9JIW8, Q86U76
    Conserved Domains (4) summary
    COG5048
    Location:139 → 317
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250 → 270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 55
    KRAB; KRAB box
    pfam13465
    Location:318 → 343
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001318135.2 → NP_001305064.1  zinc finger protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
    Source sequence(s)
    BC011887, BC025265, CA439866, DC347416
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001318136.2 → NP_001305065.1  zinc finger protein 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks two exons in its 5' UTR, contains an alternate internal segment, and uses an alternate start codon, compared to variant 3. The encoded isoform (4) has a longer and distinct N-terminus, compared to isoform 2. Variants 9, 11, and 21 all encode the same isoform (4).
    Source sequence(s)
    AK091984, BC013603, CA439866, CB988353
    UniProtKB/Swiss-Prot
    P17036
    UniProtKB/TrEMBL
    B3KRP4
    Related
    ENST00000487620.1
    Conserved Domains (4) summary
    COG5048
    Location:182 → 360
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:57 → 98
    KRAB; KRAB box
    pfam13465
    Location:361 → 386
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001318137.2 → NP_001305066.1  zinc finger protein 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) has multiple differences in the UTRs and coding region, one of which results in the use of a downstream in-frame start codon, compared to variant 3. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AC093619, AF193057, AK000223, BC011887, CB129643, DC347416
    UniProtKB/Swiss-Prot
    P17036
    Conserved Domains (2) summary
    smart00349
    Location:15 → 55
    KRAB; krueppel associated box
    pfam01352
    Location:15 → 54
    KRAB; KRAB box

  9. NM_001362775.2 → NP_001349704.1  zinc finger protein 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 9 and 21, encodes isoform 4.
    Source sequence(s)
    AK091984, BC013603, CA439866, CB988353, DA955742
    Conserved Domains (4) summary
    COG5048
    Location:182 → 360
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:57 → 98
    KRAB; KRAB box
    pfam13465
    Location:361 → 386
    zf-H2C2_2; Zinc-finger double domain

  10. NM_001362776.2 → NP_001349705.1  zinc finger protein 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC073842, BC041695, CA439866, HY096067
    Conserved Domains (4) summary
    COG5048
    Location:180 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:55 → 96
    KRAB; KRAB box
    pfam13465
    Location:359 → 384
    zf-H2C2_2; Zinc-finger double domain

  11. NM_001362777.2 → NP_001349706.1  zinc finger protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 6, 7, 19, and 20, encodes isoform 3.
    Source sequence(s)
    BC041695, BP194298, CA439866, DA623743, DA961971
    Consensus CDS
    CCDS94152.1
    UniProtKB/TrEMBL
    C9JIW8, Q86U76
    Conserved Domains (4) summary
    COG5048
    Location:139 → 317
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250 → 270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 55
    KRAB; KRAB box
    pfam13465
    Location:318 → 343
    zf-H2C2_2; Zinc-finger double domain

  12. NM_001371210.1 → NP_001358139.1  zinc finger protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC073842, AC093619
    Consensus CDS
    CCDS43618.1
    Conserved Domains (1) summary
    pfam01352
    Location:50 → 91
    KRAB; KRAB box

  13. NM_001371211.1 → NP_001358140.1  zinc finger protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 2-5, 8, and 16-18, encodes isoform 2.
    Source sequence(s)
    AC073842, AC093619
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

  14. NM_001371212.1 → NP_001358141.1  zinc finger protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 2-5, 8, 15, 17, and 18, encodes isoform 2.
    Source sequence(s)
    AC073842, AC093619
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

  15. NM_001371213.1 → NP_001358142.1  zinc finger protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 2-5, 8, 15, 16, and 18, encodes isoform 2.
    Source sequence(s)
    AC073842, AC093619
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

  16. NM_001371214.1 → NP_001358143.1  zinc finger protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 2-5, 8, and 15-17, encodes isoform 2.
    Source sequence(s)
    AC073842, AC093619
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

  17. NM_001371215.1 → NP_001358144.1  zinc finger protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 6, 7, 13, and 20, encodes isoform 3.
    Source sequence(s)
    AC073842, AC093619
    Consensus CDS
    CCDS94152.1
    UniProtKB/TrEMBL
    C9JIW8, Q86U76
    Conserved Domains (4) summary
    COG5048
    Location:139 → 317
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250 → 270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 55
    KRAB; KRAB box
    pfam13465
    Location:318 → 343
    zf-H2C2_2; Zinc-finger double domain

  18. NM_001371216.1 → NP_001358145.1  zinc finger protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variants 6, 7, 13, and 19, encodes isoform 3.
    Source sequence(s)
    AC073842, AC093619
    Consensus CDS
    CCDS94152.1
    UniProtKB/TrEMBL
    C9JIW8, Q86U76
    Conserved Domains (4) summary
    COG5048
    Location:139 → 317
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250 → 270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 55
    KRAB; KRAB box
    pfam13465
    Location:318 → 343
    zf-H2C2_2; Zinc-finger double domain

  19. NM_001371217.1 → NP_001358146.1  zinc finger protein 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variants 9 and 11, encodes isoform 4.
    Source sequence(s)
    AC073842, AC093619
    Conserved Domains (4) summary
    COG5048
    Location:182 → 360
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:57 → 98
    KRAB; KRAB box
    pfam13465
    Location:361 → 386
    zf-H2C2_2; Zinc-finger double domain

  20. NM_001371218.1 → NP_001358147.1  zinc finger protein 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC073842, AC093619
    Conserved Domains (3) summary
    COG5048
    Location:96 → 274
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:207 → 227
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:275 → 300
    zf-H2C2_2; Zinc-finger double domain

  21. NM_017715.4 → NP_060185.2  zinc finger protein 3 isoform 1

    See identical proteins and their annotated locations for NP_060185.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2. Variants 1 and 14 both encode the same isoform (1).
    Source sequence(s)
    AC093619, AF217988, AK000223
    Consensus CDS
    CCDS43618.1
    UniProtKB/Swiss-Prot
    P17036
    Related
    ENSP00000399951.2, ENST00000413658.6
    Conserved Domains (1) summary
    pfam01352
    Location:50 → 91
    KRAB; KRAB box

  22. NM_032924.5 → NP_116313.3  zinc finger protein 3 isoform 2

    See identical proteins and their annotated locations for NP_116313.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 2, 3, 4, 5, 8, and 15-18 all encode the same isoform (2).
    Source sequence(s)
    BC013603, CA439866, DC384519
    Consensus CDS
    CCDS43619.1
    UniProtKB/Swiss-Prot
    D6W5U0, P13683, P17036, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
    Related
    ENSP00000299667.4, ENST00000299667.9
    Conserved Domains (4) summary
    COG5048
    Location:175 → 353
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:50 → 91
    KRAB; KRAB box
    pfam13465
    Location:354 → 379
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100063837..100082577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420802.1 → XP_047276758.1  zinc finger protein 3 isoform X3

  2. XM_024446921.2 → XP_024302689.1  zinc finger protein 3 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:180 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:55 → 96
    KRAB; KRAB box
    pfam13465
    Location:359 → 384
    zf-H2C2_2; Zinc-finger double domain

  3. XM_024446920.2 → XP_024302688.1  zinc finger protein 3 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:180 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:55 → 96
    KRAB; KRAB box
    pfam13465
    Location:359 → 384
    zf-H2C2_2; Zinc-finger double domain

  4. XM_024446925.2 → XP_024302693.1  zinc finger protein 3 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:144 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255 → 275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:19 → 60
    KRAB; KRAB box
    pfam13465
    Location:323 → 348
    zf-H2C2_2; Zinc-finger double domain

  5. XM_024446919.2 → XP_024302687.1  zinc finger protein 3 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:180 → 358
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:55 → 96
    KRAB; KRAB box
    pfam13465
    Location:359 → 384
    zf-H2C2_2; Zinc-finger double domain

  6. XM_024446927.2 → XP_024302695.1  zinc finger protein 3 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:144 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255 → 275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:19 → 60
    KRAB; KRAB box
    pfam13465
    Location:323 → 348
    zf-H2C2_2; Zinc-finger double domain

  7. XM_024446928.2 → XP_024302696.1  zinc finger protein 3 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:144 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:255 → 275
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:19 → 60
    KRAB; KRAB box
    pfam13465
    Location:323 → 348
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101303346..101322424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358947.1 → XP_054214922.1  zinc finger protein 3 isoform X3

  2. XM_054358943.1 → XP_054214918.1  zinc finger protein 3 isoform X1

  3. XM_054358942.1 → XP_054214917.1  zinc finger protein 3 isoform X1

  4. XM_054358944.1 → XP_054214919.1  zinc finger protein 3 isoform X2

  5. XM_054358941.1 → XP_054214916.1  zinc finger protein 3 isoform X1

  6. XM_054358946.1 → XP_054214921.1  zinc finger protein 3 isoform X2

  7. XM_054358945.1 → XP_054214920.1  zinc finger protein 3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17036.3 GenPept UniProtKB/Swiss-Prot:P17036

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