Tm4sf5 transmembrane 4 superfamily member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tm4sf5provided by MGI
Official Full Name: transmembrane 4 superfamily member 5provided by MGI
Primary source: MGI:MGI:1922854
See related: Ensembl:ENSMUSG00000018919 AllianceGenome:MGI:1922854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010003F10Rik
Summary: Predicted to enable arginine binding activity. Predicted to be involved in regulation of G1/S transition of mitotic cell cycle. Predicted to be located in lysosomal membrane and plasma membrane. Predicted to be active in membrane. Is expressed in gut; peritoneum; and urinary system. Orthologous to human TM4SF5 (transmembrane 4 L six family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 230.6), small intestine adult (RPKM 174.2) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.99 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70396100..70402009)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70505274..70511183)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites.
Title: Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites.
Systemic TM4SF5 overexpression in Apc[Min/+] mice promotes hepatic portal hypertension associated with fibrosis.
Title: Systemic TM4SF5 overexpression in Apc(Min/+) mice promotes hepatic portal hypertension associated with fibrosis.
Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis.
Title: Crosstalk between TM4SF5 and GLUT8 regulates fructose metabolism in hepatic steatosis.
TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment.
Title: TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment.
TM4SF5-mediated liver malignancy involves NK cell exhaustion-like phenotypes.
Title: TM4SF5-mediated liver malignancy involves NK cell exhaustion-like phenotypes.
Tetraspanin TM4SF5 in hepatocytes negatively modulates SLC27A transporters during acute fatty acid supply.
Title: Tetraspanin TM4SF5 in hepatocytes negatively modulates SLC27A transporters during acute fatty acid supply.
Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression.
Title: Differential TM4SF5-mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression.
TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis.
Title: TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis.
Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.
Title: Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.
TM4SF5-specific monoclonal antibody has a therapeutic effect against colon cancer.
Title: Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arginine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane 4 L6 family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.