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Higd1b HIG1 domain family, member 1B [ Mus musculus (house mouse) ]

Gene ID: 75689, updated on 9-Aug-2024

Summary

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Official Symbol
Higd1bprovided by MGI
Official Full Name
HIG1 domain family, member 1Bprovided by MGI
Primary source
MGI:MGI:1922939
See related
Ensembl:ENSMUSG00000020928 AllianceGenome:MGI:1922939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310056K19Rik
Summary
Predicted to be involved in mitochondrial respirasome assembly. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Orthologous to human HIGD1B (HIG1 hypoxia inducible domain family member 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 7.4), subcutaneous fat pad adult (RPKM 2.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Higd1b in Genome Data Viewer
Location:
11 E1; 11 66.48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102726597..102728866)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102835761..102844141)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene gap junction protein, gamma 1 Neighboring gene predicted gene, 22683 Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102742482-102742665 Neighboring gene coiled-coil domain containing 103 Neighboring gene family with sequence similarity 187, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
HIG1 domain family member 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357580.2 → NP_001344509.1  HIG1 domain family member 1B

    Status: VALIDATED

    Source sequence(s)
    AL731670, BU704939
    Consensus CDS
    CCDS36345.1
    UniProtKB/Swiss-Prot
    Q8C1M5, Q99JY6
    Related
    ENSMUSP00000102688.2, ENSMUST00000107073.8
    Conserved Domains (1) summary
    pfam04588
    Location:29 → 79
    HIG_1_N; Hypoxia induced protein conserved region

  2. NM_080846.2 → NP_543122.1  HIG1 domain family member 1B

    See identical proteins and their annotated locations for NP_543122.1

    Status: VALIDATED

    Source sequence(s)
    BC005568
    Consensus CDS
    CCDS36345.1
    UniProtKB/Swiss-Prot
    Q8C1M5, Q99JY6
    Related
    ENSMUSP00000021302.9, ENSMUST00000021302.15
    Conserved Domains (1) summary
    pfam04588
    Location:29 → 79
    HIG_1_N; Hypoxia induced protein conserved region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102726597..102728866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157057.1 → XP_036012950.1  HIG1 domain family member 1B isoform X1

    UniProtKB/Swiss-Prot
    Q8C1M5, Q99JY6
    Conserved Domains (1) summary
    pfam04588
    Location:29 → 79
    HIG_1_N; Hypoxia induced protein conserved region

  2. XM_030246406.2 → XP_030102266.1  HIG1 domain family member 1B isoform X1

    UniProtKB/Swiss-Prot
    Q8C1M5, Q99JY6
    Conserved Domains (1) summary
    pfam04588
    Location:29 → 79
    HIG_1_N; Hypoxia induced protein conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JY6.1 GenPept UniProtKB/Swiss-Prot:Q99JY6

Gene LinkOut

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