U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF75A zinc finger protein 75A [ Homo sapiens (human) ]

Gene ID: 7627, updated on 26-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF75Aprovided by HGNC
Official Full Name
zinc finger protein 75Aprovided by HGNC
Primary source
HGNC:HGNC:13146
See related
Ensembl:ENSG00000162086 MIM:601473; AllianceGenome:HGNC:13146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lymph node (RPKM 3.9), testis (RPKM 3.7) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF75A in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3305497..3323465)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3332547..3350519)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3355497..3368851)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10318 Neighboring gene long intergenic non-protein coding RNA 921 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3332464-3332969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7131 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3333980-3334483 Neighboring gene zinc finger protein 263 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3354991-3355520 Neighboring gene tigger transposable element derived 7 Neighboring gene RPL7L1 pseudogene 19 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:3414288-3415487 Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-CO2 pseudogene 28 Neighboring gene MT-CO1 pseudogene 28

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes. Villa A, et al. Genomics, 1996 Jul 15. PMID 8661144
  2. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  4. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 75A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302109.2 → NP_001289038.1  zinc finger protein 75A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283, BC119652, BX324672, CR749782, DB249528
    Consensus CDS
    CCDS92095.1
    UniProtKB/TrEMBL
    A0A590UJE0
    Related
    ENSP00000499415.1, ENST00000669516.2
    Conserved Domains (8) summary
    smart00431
    Location:50 → 153
    SCAN; leucine rich region
    smart00349
    Location:235 → 296
    KRAB; krueppel associated box
    COG5048
    Location:400 → 537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:432 → 452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:486 → 508
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:235 → 274
    KRAB; KRAB box
    pfam02023
    Location:44 → 132
    SCAN; SCAN domain
    pfam13465
    Location:416 → 439
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001324041.1 → NP_001310970.1  zinc finger protein 75A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Consensus CDS
    CCDS92095.1
    UniProtKB/TrEMBL
    A0A590UJE0
    Conserved Domains (8) summary
    smart00431
    Location:50 → 153
    SCAN; leucine rich region
    smart00349
    Location:235 → 296
    KRAB; krueppel associated box
    COG5048
    Location:400 → 537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:432 → 452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:486 → 508
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:235 → 274
    KRAB; KRAB box
    pfam02023
    Location:44 → 132
    SCAN; SCAN domain
    pfam13465
    Location:416 → 439
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001324085.2 → NP_001311014.1  zinc finger protein 75A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    UniProtKB/TrEMBL
    A0A590UJ20
    Related
    ENSP00000499242.1, ENST00000498240.6
    Conserved Domains (2) summary
    smart00431
    Location:50 → 153
    SCAN; leucine rich region
    pfam02023
    Location:44 → 132
    SCAN; SCAN domain

  4. NM_001352495.2 → NP_001339424.1  zinc finger protein 75A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Conserved Domains (2) summary
    COG5048
    Location:41 → 178
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:73 → 93
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001352497.2 → NP_001339426.1  zinc finger protein 75A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Conserved Domains (2) summary
    COG5048
    Location:41 → 178
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:73 → 93
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001352498.2 → NP_001339427.1  zinc finger protein 75A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Conserved Domains (2) summary
    COG5048
    Location:41 → 178
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:73 → 93
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_153028.4 → NP_694573.1  zinc finger protein 75A isoform 2

    See identical proteins and their annotated locations for NP_694573.1

    Status: VALIDATED

    Source sequence(s)
    AC025283, AK056091, CR749782
    Consensus CDS
    CCDS10501.1
    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20
    Related
    ENSP00000459566.1, ENST00000574298.6
    Conserved Domains (3) summary
    smart00349
    Location:1 → 55
    KRAB; krueppel associated box
    COG5048
    Location:159 → 296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3305497..3323465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434593.1 → XP_047290549.1  zinc finger protein 75A isoform X7

  2. XM_017023645.3 → XP_016879134.1  zinc finger protein 75A isoform X7

    UniProtKB/TrEMBL
    A0A590UJ20

  3. XM_017023644.3 → XP_016879133.1  zinc finger protein 75A isoform X5

    UniProtKB/TrEMBL
    A0A590UJ20

  4. XM_047434588.1 → XP_047290544.1  zinc finger protein 75A isoform X2

  5. XM_047434587.1 → XP_047290543.1  zinc finger protein 75A isoform X1

    UniProtKB/TrEMBL
    A0A590UJE0

  6. XM_047434589.1 → XP_047290545.1  zinc finger protein 75A isoform X3

    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20

  7. XM_047434590.1 → XP_047290546.1  zinc finger protein 75A isoform X3

    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20

  8. XM_047434591.1 → XP_047290547.1  zinc finger protein 75A isoform X3

    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20

  9. XM_011522646.4 → XP_011520948.1  zinc finger protein 75A isoform X2

    Conserved Domains (8) summary
    smart00431
    Location:50 → 153
    SCAN; leucine rich region
    smart00349
    Location:235 → 294
    KRAB; krueppel associated box
    COG5048
    Location:363 → 500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:395 → 415
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:449 → 471
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:235 → 274
    KRAB; KRAB box
    pfam02023
    Location:44 → 132
    SCAN; SCAN domain
    pfam13465
    Location:379 → 402
    zf-H2C2_2; Zinc-finger double domain

  10. XM_047434592.1 → XP_047290548.1  zinc finger protein 75A isoform X6

  11. XM_017023643.3 → XP_016879132.1  zinc finger protein 75A isoform X4

    UniProtKB/TrEMBL
    A0A590UJ20

  12. XM_011522647.3 → XP_011520949.1  zinc finger protein 75A isoform X3

    See identical proteins and their annotated locations for XP_011520949.1

    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20
    Related
    ENSP00000482769.1, ENST00000617839.1
    Conserved Domains (3) summary
    smart00349
    Location:1 → 55
    KRAB; krueppel associated box
    COG5048
    Location:159 → 296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3332547..3350519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313848.1 → XP_054169823.1  zinc finger protein 75A isoform X7

  2. XM_054313847.1 → XP_054169822.1  zinc finger protein 75A isoform X7

  3. XM_054313845.1 → XP_054169820.1  zinc finger protein 75A isoform X5

  4. XM_054313840.1 → XP_054169815.1  zinc finger protein 75A isoform X2

  5. XM_054313841.1 → XP_054169816.1  zinc finger protein 75A isoform X3

    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20

  6. XM_054313842.1 → XP_054169817.1  zinc finger protein 75A isoform X3

    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20

  7. XM_054313843.1 → XP_054169818.1  zinc finger protein 75A isoform X3

    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20

  8. XM_054313839.1 → XP_054169814.1  zinc finger protein 75A isoform X2

  9. XM_054313846.1 → XP_054169821.1  zinc finger protein 75A isoform X6

  10. XM_054313844.1 → XP_054169819.1  zinc finger protein 75A isoform X4

  11. XM_054313838.1 → XP_054169813.1  zinc finger protein 75A isoform X1

    UniProtKB/TrEMBL
    A0A590UJE0

  12. XM_054313849.1 → XP_054169824.1  zinc finger protein 75A isoform X3

    UniProtKB/Swiss-Prot
    Q0VDI8, Q92669, Q96N20
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96N20.1 GenPept UniProtKB/Swiss-Prot:Q96N20

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous