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Ip6k2 inositol hexaphosphate kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 76500, updated on 28-Oct-2024

Summary

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Official Symbol
Ip6k2provided by MGI
Official Full Name
inositol hexaphosphate kinase 2provided by MGI
Primary source
MGI:MGI:1923750
See related
Ensembl:ENSMUSG00000032599 AllianceGenome:MGI:1923750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ihpk2; 1500005N04Rik
Summary
Enables inositol hexakisphosphate kinase activity. Involved in inositol phosphate biosynthetic process. Acts upstream of or within positive regulation of peptidyl-serine phosphorylation and protein stabilization. Located in nucleus. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human IP6K2 (inositol hexakisphosphate kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 56.3), whole brain E14.5 (RPKM 54.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ip6k2 in Genome Data Viewer
Location:
9 F2; 9 59.63 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108660928..108683532)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108783764..108806333)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8317 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene protein kinase, cAMP dependent regulatory, type II alpha Neighboring gene STARR-seq mESC enhancer starr_25223 Neighboring gene predicted gene, 24259 Neighboring gene STARR-seq mESC enhancer starr_25226 Neighboring gene STARR-positive B cell enhancer ABC_E2307 Neighboring gene predicted gene, 23034 Neighboring gene NCK interacting protein with SH3 domain Neighboring gene predicted gene, 35025

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP(7) metabolism in the enteric nervous system. Ito M, et al. J Biol Chem, 2023 Mar. PMID 36681123, Free PMC Article
  2. Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling. Nagpal L, et al. Proc Natl Acad Sci U S A, 2022 Apr 5. PMID 35353626, Free PMC Article
  3. Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N. Nagpal L, et al. J Neurosci, 2018 Aug 22. PMID 30006360, Free PMC Article
  4. Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Morrison BH, et al. Oncogene, 2009 Jun 25. PMID 19430495, Free PMC Article
  5. Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. Rao F, et al. Proc Natl Acad Sci U S A, 2015 Feb 10. PMID 25617365, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
    Title: The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
  2. Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling.
    Title: Inositol hexakisphosphate kinase-2 non-catalytically regulates mitophagy by attenuating PINK1 signaling.
  3. Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B.
    Title: Inositol hexakisphosphate kinase-2 determines cellular energy dynamics by regulating creatine kinase-B.
  4. IP6K2 binds selectively to the neuronal protein 4.1N. Both are highly expressed in granule cells of the cerebellum. In IP6K2 knock-out mice, IP6K2-4.1N interactions in granule cells regulate Purkinje cell morphology, the viability of cerebellar neurons, and psychomotor behavior.
    Title: Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N.
  5. IP6K2 is a major mediator of cancer cell migration and tumor metastasis, acting by enhancing cell-matrix adhesion and decreasing cell-cell adhesion.
    Title: Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.
  6. FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression.
    Title: The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade.
  7. Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
    Title: Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107719

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavonoid binding ISO
Inferred from Sequence Orthology
more info
  
enables flavonoid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol hexakisphosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol hexakisphosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol hexakisphosphate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inositol hexakisphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to flavonoid ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to flavonoid ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inositol phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inositol hexakisphosphate kinase 2
Names
insP6 kinase 2
p(i)-uptake stimulator
piUS
NP_001366529.1
NP_001366530.1
NP_001366531.1
NP_001366532.1
NP_083910.2
XP_006511914.1
XP_006511916.1
XP_006511917.1
XP_006511918.1
XP_006511919.1
XP_036011296.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379600.1 → NP_001366529.1  inositol hexakisphosphate kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC168054, AC173341
    Conserved Domains (1) summary
    pfam03770
    Location:202 → 417
    IPK; Inositol polyphosphate kinase

  2. NM_001379601.1 → NP_001366530.1  inositol hexakisphosphate kinase 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC168054, AC173341
    UniProtKB/Swiss-Prot
    E9QMT6, Q80V72
    Conserved Domains (1) summary
    pfam03770
    Location:225 → 440
    IPK; Inositol polyphosphate kinase

  3. NM_001379602.1 → NP_001366531.1  inositol hexakisphosphate kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC168054, AC173341
    Conserved Domains (1) summary
    pfam03770
    Location:202 → 417
    IPK; Inositol polyphosphate kinase

  4. NM_001379603.1 → NP_001366532.1  inositol hexakisphosphate kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC168054, AC173341
    UniProtKB/TrEMBL
    A0A0A6YWM3
    Related
    ENSMUSP00000141605.2, ENSMUST00000193560.6
    Conserved Domains (1) summary
    pfam03770
    Location:179 → 394
    IPK; Inositol polyphosphate kinase

  5. NM_029634.2 → NP_083910.2  inositol hexakisphosphate kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_083910.2

    Status: VALIDATED

    Source sequence(s)
    AC168054
    Consensus CDS
    CCDS23537.1
    UniProtKB/Swiss-Prot
    E9QMT6, Q80V72
    Related
    ENSMUSP00000082091.5, ENSMUST00000085018.6
    Conserved Domains (1) summary
    pfam03770
    Location:225 → 440
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108660928..108683532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511853.3 → XP_006511916.1  inositol hexakisphosphate kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006511916.1

  2. XM_006511855.3 → XP_006511918.1  inositol hexakisphosphate kinase 2 isoform X3

  3. XM_006511856.4 → XP_006511919.1  inositol hexakisphosphate kinase 2 isoform X4

    See identical proteins and their annotated locations for XP_006511919.1

    UniProtKB/TrEMBL
    A0A0A6YXT7
    Related
    ENSMUSP00000142134.2, ENSMUST00000192307.6

  4. XM_036155403.1 → XP_036011296.1  inositol hexakisphosphate kinase 2 isoform X3

  5. XM_006511851.5 → XP_006511914.1  inositol hexakisphosphate kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006511914.1

    UniProtKB/Swiss-Prot
    E9QMT6, Q80V72
    Conserved Domains (1) summary
    pfam03770
    Location:225 → 440
    IPK; Inositol polyphosphate kinase

  6. XM_006511854.5 → XP_006511917.1  inositol hexakisphosphate kinase 2 isoform X2

    See identical proteins and their annotated locations for XP_006511917.1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80V72.2 GenPept UniProtKB/Swiss-Prot:Q80V72

Gene LinkOut

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