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tubb4bl tubulin, beta 4B class IVb-like [ Danio rerio (zebrafish) ]

Gene ID: 767746, updated on 2-Nov-2024

Summary

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Official Symbol
tubb4blprovided by ZNC
Official Full Name
tubulin, beta 4B class IVb-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-220
See related
Ensembl:ENSDARG00000104436 AllianceGenome:ZFIN:ZDB-GENE-060929-220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj41e11; wu:fj41e11; zgc:153426
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 6 and torsion dystonia 4. Orthologous to human TUBB4A (tubulin beta 4A class IVa). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See tubb4bl in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (49559259..49566364, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (45413848..45420953, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene crumbs homolog 3a Neighboring gene uncharacterized LOC793338 Neighboring gene uncharacterized LOC103910317 Neighboring gene uncharacterized LOC103910318 Neighboring gene zinc-binding protein A33 Neighboring gene G-protein coupled receptor 183-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins. Zeng J, et al. Nucleic Acids Res, 2008 Jan. PMID 18086703, Free PMC Article
  2. Systematic transcriptome analysis of the zebrafish model of diamond-blackfan anemia induced by RPS24 deficiency. Song B, et al. BMC Genomics, 2014 Sep 4. PMID 25189322, Free PMC Article
  3. Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Teixeira CMM, et al. Zebrafish, 2019 Jun. PMID 31017557
  4. Unilateral dampening of Bmp activity by nodal generates cardiac left-right asymmetry. Veerkamp J, et al. Dev Cell, 2013 Mar 25. PMID 23499359
  5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC153426

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC767746
Names
tubulin beta-4B chain-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076715.2 → NP_001070183.1  uncharacterized protein LOC767746

    See identical proteins and their annotated locations for NP_001070183.1

    Status: VALIDATED

    Source sequence(s)
    BC124348
    UniProtKB/TrEMBL
    Q08C80
    Related
    ENSDARP00000130980.1, ENSDART00000161507.2
    Conserved Domains (2) summary
    PLN00220
    Location:1 → 430
    PLN00220; tubulin beta chain; Provisional
    cd02187
    Location:2 → 426
    beta_tubulin; The beta-tubulin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    49559259..49566364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Research Materials