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abcd4 ATP-binding cassette, sub-family D (ALD), member 4 [ Danio rerio (zebrafish) ]

Gene ID: 767748, updated on 2-Nov-2024

Summary

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Official Symbol
abcd4provided by ZNC
Official Full Name
ATP-binding cassette, sub-family D (ALD), member 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-050517-30
See related
Ensembl:ENSDARG00000061770 AllianceGenome:ZFIN:ZDB-GENE-050517-30
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153503
Summary
Predicted to enable ATP binding activity; ATPase-coupled transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Predicted to be involved in fatty acid catabolic process; long-chain fatty acid import into peroxisome; and peroxisome organization. Predicted to act upstream of or within transmembrane transport. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in endoderm; head; intermediate cell mass of mesoderm; muscle; and pronephric duct. Used to study vitamin B12 deficiency. Orthologous to human ABCD4 (ATP binding cassette subfamily D member 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See abcd4 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (35910962..35930395)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (36022864..36042221)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 178 Neighboring gene kelch-like family member 14 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b Neighboring gene guanine nucleotide-binding protein G(s) subunit alpha Neighboring gene im:7140347

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Loss of abcd4 in zebrafish leads to vitamin B(12)-deficiency anemia. Choi YM, et al. Biochem Biophys Res Commun, 2019 Jul 5. PMID 31113616
  2. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
  3. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
  4. Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. Ren J, et al. BMC Genomics, 2015 Jun 6. PMID 26047617, Free PMC Article
  5. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC153503

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid import into peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in very long-chain fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lysosomal cobalamin transporter ABCD4
NP_001070185.2
XP_005162924.1
XP_021325897.1
XP_068073222.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076717.2 → NP_001070185.2  lysosomal cobalamin transporter ABCD4

    Status: VALIDATED

    Source sequence(s)
    BX293567, CR792456
    UniProtKB/TrEMBL
    A0A8M1NB84, F1Q4Y1
    Related
    ENSDARP00000110201.2, ENSDART00000129679.3
    Conserved Domains (3) summary
    cd03223
    Location:385 → 596
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    COG4178
    Location:18 → 603
    YddA; ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]
    cl00549
    Location:14 → 292
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    35910962..35930395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470222.2 → XP_021325897.1  lysosomal cobalamin transporter ABCD4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9P5Z5
    Conserved Domains (1) summary
    COG4178
    Location:18 → 589
    YddA; ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]

  2. XM_005162867.5 → XP_005162924.1  lysosomal cobalamin transporter ABCD4 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B9T8
    Conserved Domains (3) summary
    cd03223
    Location:231 → 442
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    COG4133
    Location:244 → 436
    CcmA; ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]
    cl00549
    Location:1 → 138
    ABC_membrane; ABC transporter transmembrane region

  3. XM_068217121.1 → XP_068073222.1  lysosomal cobalamin transporter ABCD4 isoform X2

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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