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pdgfab platelet-derived growth factor alpha polypeptide b [ Danio rerio (zebrafish) ]

Gene ID: 767790, updated on 2-Nov-2024

Summary

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Official Symbol
pdgfabprovided by ZNC
Official Full Name
platelet-derived growth factor alpha polypeptide bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-124
See related
Ensembl:ENSDARG00000098578 AllianceGenome:ZFIN:ZDB-GENE-060929-124
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc32c12; zgc:153249
Summary
Predicted to enable platelet-derived growth factor receptor binding activity. Involved in angiogenesis. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in endoderm; mouth; pharyngeal arch; pharyngeal endoderm; and pharyngeal pouch. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See pdgfab in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (12925342..12970418, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (12773481..12819035, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene BTB (POZ) domain containing 17b Neighboring gene coiled-coil domain containing 137 Neighboring gene protein kinase, cAMP-dependent, regulatory, type I, beta Neighboring gene centriolar coiled-coil protein of 110 kDa-like Neighboring gene dynein axonemal assembly factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. PDGF signaling from pharyngeal pouches promotes arch artery morphogenesis. Mao A, et al. J Genet Genomics, 2019 Dec 20. PMID 31974005
  2. MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Eberhart JK, et al. Nat Genet, 2008 Mar. PMID 18264099, Free PMC Article
  3. Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis. Owen N, et al. Genet Med, 2022 May. PMID 35034853, Free PMC Article
  4. Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish. Lovely CB, et al. Development, 2016 Jun 1. PMID 27122171, Free PMC Article
  5. Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. Bloomekatz J, et al. Elife, 2017 Jan 18. PMID 28098558, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC153249

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
platelet-derived growth factor alpha polypeptide b
Names
platelet derived growth factor alpha b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076757.1 → NP_001070225.1  platelet-derived growth factor alpha polypeptide b precursor

    See identical proteins and their annotated locations for NP_001070225.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124288
    UniProtKB/TrEMBL
    Q08CD2
    Related
    ENSDARP00000140240.1, ENSDART00000158747.2
    Conserved Domains (2) summary
    pfam00341
    Location:105 → 189
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:22 → 104
    PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    12925342..12970418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163736.5 → XP_005163793.1  platelet-derived growth factor alpha polypeptide b isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAV6
    Conserved Domains (2) summary
    pfam00341
    Location:105 → 189
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:22 → 104
    PDGF_N; Platelet-derived growth factor, N terminal region

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394521.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    102511..146600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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