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cnot7 CCR4-NOT transcription complex, subunit 7 [ Danio rerio (zebrafish) ]

Gene ID: 768119, updated on 17-Sep-2024

Summary

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Official Symbol
cnot7provided by ZNC
Official Full Name
CCR4-NOT transcription complex, subunit 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-29
See related
Ensembl:ENSDARG00000032116 AllianceGenome:ZFIN:ZDB-GENE-061013-29
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CAF1; fd59c07; fj07d05; wu:fd59c07; wu:fj07d05; zgc:153168
Summary
Predicted to enable poly(A)-specific ribonuclease activity. Acts upstream of or within mRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See cnot7 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (30413753..30424861)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (30073444..30084542)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 2 Neighboring gene myotubularin related protein 7a Neighboring gene zinc finger DHHC-type palmitoyltransferase 2 Neighboring gene mitochondrial calcium uptake family, member 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Deadenylation by the CCR4-NOT complex contributes to the turnover of hairy-related mRNAs in the zebrafish segmentation clock. Fujino Y, et al. FEBS Lett, 2018 Oct. PMID 30281784
  2. Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish. Mishima Y, et al. Genes Cells, 2017 Jul. PMID 28557307
  3. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish. Mishima Y, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22232654, Free PMC Article
  4. Roles of mRNA fate modulators Dhh1 and Pat1 in TNRC6-dependent gene silencing recapitulated in yeast. Makino S, et al. J Biol Chem, 2015 Mar 27. PMID 25657010, Free PMC Article
  5. Codon Usage and 3' UTR Length Determine Maternal mRNA Stability in Zebrafish. Mishima Y, et al. Mol Cell, 2016 Mar 17. PMID 26990990

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show pervasive yet nonuniform contributions of the decapping enzyme Dcp2 and the deadenylase Cnot7 to maternal mRNA clearance.
    Title: Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA-mediated gene silencing by mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated gene silencing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex IEA
Inferred from Electronic Annotation
more info
  
part_of CCR4-NOT complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of CCR4-NOT core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 7
Names
CAF-1
CCR4-associated factor 1
NP_001070723.1
XP_021336741.1
XP_068069348.1
XP_068069349.1
XP_068069350.1
XP_068069351.1
XP_068069352.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077255.1 → NP_001070723.1  CCR4-NOT transcription complex subunit 7

    See identical proteins and their annotated locations for NP_001070723.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124650
    UniProtKB/Swiss-Prot
    Q08BM8
    Related
    ENSDARP00000087385.5, ENSDART00000092953.7
    Conserved Domains (1) summary
    cl23804
    Location:1 → 279
    CAF1; CAF1 family ribonuclease

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    30413753..30424861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213247.1 → XP_068069348.1  CCR4-NOT transcription complex subunit 7 isoform X1

  2. XM_068213248.1 → XP_068069349.1  CCR4-NOT transcription complex subunit 7 isoform X2

  3. XM_021481066.2 → XP_021336741.1  CCR4-NOT transcription complex subunit 7 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QKP5
    Conserved Domains (1) summary
    cl23804
    Location:1 → 288
    CAF1; CAF1 family ribonuclease

  4. XM_068213251.1 → XP_068069352.1  CCR4-NOT transcription complex subunit 7 isoform X6

  5. XM_068213250.1 → XP_068069351.1  CCR4-NOT transcription complex subunit 7 isoform X5

    Related
    ENSDARP00000113903.1, ENSDART00000136009.2

  6. XM_068213249.1 → XP_068069350.1  CCR4-NOT transcription complex subunit 7 isoform X4

    Related
    ENSDARP00000156128.1, ENSDART00000186864.1

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394914.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    343937..354772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08BM8.1 GenPept UniProtKB/Swiss-Prot:Q08BM8

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