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me1 malic enzyme 1, NADP(+)-dependent, cytosolic [ Danio rerio (zebrafish) ]

Gene ID: 768196, updated on 10-Nov-2024

Summary

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Official Symbol
me1provided by ZNC
Official Full Name
malic enzyme 1, NADP(+)-dependent, cytosolicprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-438
See related
Ensembl:ENSDARG00000053215 AllianceGenome:ZFIN:ZDB-GENE-061013-438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153079
Summary
Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human ME1 (malic enzyme 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See me1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (32843317..32988712, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (32889287..33047103, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487925 Neighboring gene PR domain containing 13 Neighboring gene melanin concentrating hormone receptor 2a Neighboring gene serine protease 35 Neighboring gene synaptosome associated protein 91a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Holowiecki A, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2017 Jan. PMID 27760386, Free PMC Article
  2. Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. Rocha F, et al. Br J Nutr, 2015 Feb 14. PMID 25609020
  3. Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model. Gao SY, et al. Front Pharmacol, 2024. PMID 38449808, Free PMC Article
  4. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). Rocha F, et al. J Exp Biol, 2014 Apr 1. PMID 24363414
  5. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Pan YX, et al. Aquat Toxicol, 2018 Jun. PMID 29604498

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables malic enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADP-dependent malic enzyme
NP_001296966.1
XP_005158426.1
XP_068070118.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310037.1 → NP_001296966.1  NADP-dependent malic enzyme

    See identical proteins and their annotated locations for NP_001296966.1

    Status: VALIDATED

    Source sequence(s)
    BC152078
    UniProtKB/TrEMBL
    A7MC82
    Related
    ENSDARP00000092744.5, ENSDART00000101969.6
    Conserved Domains (3) summary
    cd05312
    Location:273 → 550
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:4 → 552
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:82 → 263
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    32843317..32988712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158369.5 → XP_005158426.1  NADP-dependent malic enzyme isoform X1

    See identical proteins and their annotated locations for XP_005158426.1

    UniProtKB/TrEMBL
    A0A8M6Z1U3
    Conserved Domains (3) summary
    cd05312
    Location:243 → 520
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PRK13529
    Location:2 → 525
    PRK13529; malate dehydrogenase; Provisional
    pfam00390
    Location:52 → 233
    malic; Malic enzyme, N-terminal domain

  2. XM_068214017.1 → XP_068070118.1  NADP-dependent malic enzyme isoform X1

    Related
    ENSDARP00000113885.2, ENSDART00000147941.3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001077338.1: Suppressed sequence

    Description
    NM_001077338.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version

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