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Hnrnpm heterogeneous nuclear ribonucleoprotein M [ Mus musculus (house mouse) ]

Gene ID: 76936, updated on 4-Jan-2025

Summary

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Official Symbol
Hnrnpmprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Mprovided by MGI
Primary source
MGI:MGI:1926465
See related
Ensembl:ENSMUSG00000059208 AllianceGenome:MGI:1926465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpm; mKIAA4193; 2610023M21Rik
Summary
Predicted to enable several functions, including calcium-dependent protein binding activity; mRNA binding activity; and protein antigen binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome; positive regulation of protein localization; and regulation of postsynapse organization. Located in collagen-containing extracellular matrix. Is active in synapse. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and olfactory epithelium. Orthologous to human HNRNPM (heterogeneous nuclear ribonucleoprotein M). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 154.1), liver E14 (RPKM 82.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Hnrnpm in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33865207..33904432, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33646233..33685458, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42409 Neighboring gene zinc finger protein 414 Neighboring gene PML-RAR alpha-regulated adaptor molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E10946 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7520 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E82 Neighboring gene RAB11B, member RAS oncogene family, opposite strand 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity. Akinyemi AR, et al. Neurosci Lett, 2021 Apr 23. PMID 33727124
  2. The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages. West KO, et al. Cell Rep, 2019 Nov 5. PMID 31693898, Free PMC Article
  3. Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation. Chen WY, et al. Sci Rep, 2017 Jan 20. PMID 28106162, Free PMC Article
  4. Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA. Park E, et al. J Biol Chem, 2011 Jul 15. PMID 21622564, Free PMC Article
  5. Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development. Mahé D, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004512

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.
    Title: hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.
  2. The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.
    Title: The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.
  3. Results have identified a novel Rictor associated protein, hnRNPM which was found to be able to affect the phosphorylation of SGK1 S422, a direct phosphorylation site of mTORC2. hnRNP M seem to mediate the SGK1 signaling that regulates muscle differentiation.
    Title: Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation.
  4. identify Nova-1 and hnRNP M as D2R pre-mRNA-binding proteins and show their antagonistic role in the alternative splicing of D2R pre-mRNA.
    Title: Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4193

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in paraspeckles IEA
Inferred from Electronic Annotation
more info
  
located_in paraspeckles ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein M
Names
hnRNP M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109913.1 → NP_001103383.1  heterogeneous nuclear ribonucleoprotein M isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1, which results in shorter protein (isoform b) when compared to isoform a.
    Source sequence(s)
    AK220299, BC054785
    Consensus CDS
    CCDS50068.1
    UniProtKB/TrEMBL
    Q3THB3, Q3TW40
    Related
    ENSMUSP00000084864.6, ENSMUST00000087582.13
    Conserved Domains (5) summary
    COG0724
    Location:615 → 690
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:166 → 239
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12661
    Location:614 → 690
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:40 → 69
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    cl17169
    Location:71 → 146
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_029804.3 → NP_084080.1  heterogeneous nuclear ribonucleoprotein M isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK220299, BC054785
    Consensus CDS
    CCDS37570.1
    UniProtKB/Swiss-Prot
    Q6P1B2, Q99JQ0, Q9D0E1
    UniProtKB/TrEMBL
    Q3TW40
    Related
    ENSMUSP00000120115.2, ENSMUST00000148178.8
    Conserved Domains (5) summary
    COG0724
    Location:654 → 729
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12386
    Location:205 → 278
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12657
    Location:71 → 146
    RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    cd12661
    Location:653 → 729
    RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    pfam11532
    Location:40 → 69
    HnRNP_M; Heterogeneous nuclear ribonucleoprotein M

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33865207..33904432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0E1.3 GenPept UniProtKB/Swiss-Prot:Q9D0E1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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