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ZNF135 zinc finger protein 135 [ Homo sapiens (human) ]

Gene ID: 7694, updated on 17-Sep-2024

Summary

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Official Symbol
ZNF135provided by HGNC
Official Full Name
zinc finger protein 135provided by HGNC
Primary source
HGNC:HGNC:12919
See related
Ensembl:ENSG00000176293 MIM:604077; AllianceGenome:HGNC:12919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pT3; ZNF61; pHZ-17; ZNF78L1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary (RPKM 3.4), endometrium (RPKM 3.3) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZNF135 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58059239..58069755)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61156060..61166554)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58570607..58581123)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 1 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 pseudogene 2 Neighboring gene HNRNPDL pseudogene 4 Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene Neighboring gene zinc finger and SCAN domain containing 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chromosomal localization of four human zinc finger cDNAs. Huebner K, et al. Hum Genet, 1993 Apr. PMID 8478004
  2. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Tommerup N, et al. Genomics, 1995 May 20. PMID 7557990
  3. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. Bai SW, et al. BMC Biol, 2011 Aug 11. PMID 21834987, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 135
Names
zinc finger protein 135 (clone pHZ-17)
zinc finger protein 61
zinc finger protein 78-like 1 (pT3)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164527.1 → NP_001157999.1  zinc finger protein 135 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK094202, CN367970, DA232862, DB117846
    UniProtKB/TrEMBL
    Q8N9M3
    Conserved Domains (2) summary
    smart00349
    Location:26 → 85
    KRAB; krueppel associated box
    pfam01352
    Location:26 → 65
    KRAB; KRAB box

  2. NM_001164529.1 → NP_001158001.1  zinc finger protein 135 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4 which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK094202, AK098011, AL833637, BX647775, DB117846, DB304820
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    Q8N9M3
    Conserved Domains (2) summary
    smart00349
    Location:26 → 85
    KRAB; krueppel associated box
    pfam01352
    Location:26 → 65
    KRAB; KRAB box

  3. NM_001164530.1 → NP_001158002.1  zinc finger protein 135 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate segments in the coding region, one of which results in a frameshift, compared to variant 1. The encoded isoform 5 is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK094202, AK098011, AK297226, BX647775, DB304820
    Consensus CDS
    CCDS54330.1
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    B4DLZ7, Q8N9M3
    Related
    ENSP00000369437.4, ENST00000359978.10
    Conserved Domains (6) summary
    smart00349
    Location:26 → 85
    KRAB; krueppel associated box
    COG5048
    Location:148 → 389
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:228 → 248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:26 → 65
    KRAB; KRAB box
    pfam13465
    Location:352 → 377
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001289401.2 → NP_001276330.1  zinc finger protein 135 isoform 6

    See identical proteins and their annotated locations for NP_001276330.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, and includes an alternate exon that results in a distinct 5' UTR and uses of an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094202, AL833637, BC046434, BM993886, BX647775
    Consensus CDS
    CCDS74471.1
    UniProtKB/Swiss-Prot
    B4DHH9, E9PEV2, F5GYY9, I3L0B3, P52742, Q5U5L3, Q8N1I7
    Related
    ENSP00000321406.5, ENST00000313434.10
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:240 → 641
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:440 → 460
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:214 → 236
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:480 → 505
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001289402.2 → NP_001276331.1  zinc finger protein 135 isoform 7

    See identical proteins and their annotated locations for NP_001276331.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 3' coding region, and includes an alternate exon that results in a distinct 5' UTR and uses of a downstream start codon, compared to variant 1. The encoded isoform (7) is shorter, compared to isoform 1.
    Source sequence(s)
    AK094202, AL833637, BC046434, BM993886, BX647775
    Consensus CDS
    CCDS74472.1
    UniProtKB/TrEMBL
    Q8N9M3
    Related
    ENSP00000427691.1, ENST00000506786.1
    Conserved Domains (3) summary
    COG5048
    Location:198 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:398 → 418
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:438 → 463
    zf-H2C2_2; Zinc-finger double domain

  6. NM_003436.4 → NP_003427.3  zinc finger protein 135 isoform 2

    See identical proteins and their annotated locations for NP_003427.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon that results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094202, AK098011, AK295110, BX647775, DB304820
    Consensus CDS
    CCDS12970.2
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    Q8N9M3
    Related
    ENSP00000422074.1, ENST00000511556.5
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:252 → 653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain

  7. NM_007134.1 → NP_009065.1  zinc finger protein 135 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK094202, AK098011, BX647775, DB117846, DB304820
    Consensus CDS
    CCDS54329.1
    UniProtKB/Swiss-Prot
    P52742
    UniProtKB/TrEMBL
    Q8N9M3
    Related
    ENSP00000441410.1, ENST00000401053.8
    Conserved Domains (6) summary
    smart00349
    Location:26 → 85
    KRAB; krueppel associated box
    COG5048
    Location:264 → 665
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:464 → 484
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:238 → 260
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:26 → 65
    KRAB; KRAB box
    pfam13465
    Location:504 → 529
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58059239..58069755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723362.5 → XP_006723425.1  zinc finger protein 135 isoform X1

    See identical proteins and their annotated locations for XP_006723425.1

    UniProtKB/Swiss-Prot
    P52742
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:252 → 653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047439362.1 → XP_047295318.1  zinc finger protein 135 isoform X3

    UniProtKB/Swiss-Prot
    B4DHH9, E9PEV2, F5GYY9, I3L0B3, P52742, Q5U5L3, Q8N1I7

  3. XM_005259211.2 → XP_005259268.1  zinc finger protein 135 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:26 → 85
    KRAB; krueppel associated box
    COG5048
    Location:252 → 653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:26 → 65
    KRAB; KRAB box
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006723363.4 → XP_006723426.1  zinc finger protein 135 isoform X1

    See identical proteins and their annotated locations for XP_006723426.1

    UniProtKB/Swiss-Prot
    P52742
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:252 → 653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:226 → 248
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:492 → 517
    zf-H2C2_2; Zinc-finger double domain

  5. XM_047439363.1 → XP_047295319.1  zinc finger protein 135 isoform X3

    UniProtKB/Swiss-Prot
    B4DHH9, E9PEV2, F5GYY9, I3L0B3, P52742, Q5U5L3, Q8N1I7

  6. XM_047439364.1 → XP_047295320.1  zinc finger protein 135 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61156060..61166554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322003.1 → XP_054177978.1  zinc finger protein 135 isoform X1

  2. XM_054322006.1 → XP_054177981.1  zinc finger protein 135 isoform X3

  3. XM_054322005.1 → XP_054177980.1  zinc finger protein 135 isoform X2

  4. XM_054322007.1 → XP_054177982.1  zinc finger protein 135 isoform X3

  5. XM_054322004.1 → XP_054177979.1  zinc finger protein 135 isoform X1

  6. XM_054322008.1 → XP_054177983.1  zinc finger protein 135 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52742.3 GenPept UniProtKB/Swiss-Prot:P52742

Gene LinkOut

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