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ZNF138 zinc finger protein 138 [ Homo sapiens (human) ]

Gene ID: 7697, updated on 26-Nov-2024

Summary

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Official Symbol
ZNF138provided by HGNC
Official Full Name
zinc finger protein 138provided by HGNC
Primary source
HGNC:HGNC:12922
See related
Ensembl:ENSG00000197008 MIM:604080; AllianceGenome:HGNC:12922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pHZ-32
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 2.7), testis (RPKM 2.2) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF138 in Genome Data Viewer
Location:
7q11.21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64794428..64860823)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (66001955..66067000)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64254806..64321201)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 107 Neighboring gene BCL2 interacting protein 3 pseudogene 11 Neighboring gene microRNA 6839 Neighboring gene myelin protein zero like 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26063 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:64254846-64255406 Neighboring gene CRISPRi-validated cis-regulatory element chr7.2319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64315844-64316400 Neighboring gene selenophosphate synthetase 1 pseudogene 1 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64348006-64348724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64348725-64349442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64350161-64350877 Neighboring gene uncharacterized LOC441239 Neighboring gene zinc finger protein 273

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide and candidate gene association study of cigarette smoking behaviors. Caporaso N, et al. PLoS One, 2009. PMID 19247474, Free PMC Article
  2. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Tommerup N, et al. Genomics, 1995 May 20. PMID 7557990
  3. The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification. Helleboid PY, et al. EMBO J, 2019 Sep 16. PMID 31403225, Free PMC Article
  4. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  5. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 138
Names
zinc finger protein 138 (clone pHZ-32)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160183.3 → NP_001153655.1  zinc finger protein 138 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes two alternate exons in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS55115.1
    UniProtKB/TrEMBL
    A0A0A0MT90
    Related
    ENSP00000419197.1, ENST00000494380.5
    Conserved Domains (2) summary
    smart00349
    Location:4 → 57
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

  2. NM_001271637.2 → NP_001258566.1  zinc finger protein 138 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate exon, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS64659.1
    UniProtKB/TrEMBL
    C9JHF6
    Related
    ENSP00000415995.1, ENST00000440598.2
    Conserved Domains (2) summary
    smart00349
    Location:4 → 50
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

  3. NM_001271638.2 → NP_001258567.2  zinc finger protein 138 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an alternate exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS64661.1
    UniProtKB/TrEMBL
    E7EWC5
    Related
    ENSP00000399528.1, ENST00000437743.1

  4. NM_001271639.2 → NP_001258568.2  zinc finger protein 138 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes an alternate in-frame exon, compared to variant 1. The encoded isoform (6) is longer than isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS64660.1
    UniProtKB/TrEMBL
    J3QSS9
    Related
    ENSP00000303533.7, ENST00000307355.12

  5. NM_001271640.2 → NP_001258569.1  zinc finger protein 138 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (7) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS75607.1
    UniProtKB/TrEMBL
    A0A0A0MRG3
    Related
    ENSP00000352770.4, ENST00000359735.7
    Conserved Domains (2) summary
    smart00349
    Location:4 → 43
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

  6. NM_001271649.2 → NP_001258578.1  zinc finger protein 138 isoform 4

    See identical proteins and their annotated locations for NP_001258578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate coding exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC073349
    UniProtKB/TrEMBL
    A2RRP7
    Related
    ENST00000430838.2
    Conserved Domains (2) summary
    COG5189
    Location:72 → 155
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:50 → 70
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001367572.1 → NP_001354501.1  zinc finger protein 138 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC073349
    UniProtKB/Swiss-Prot
    B4DFX2, B4DP87, E9PHI7, E9PHK7, P52744

  8. NM_001367573.1 → NP_001354502.1  zinc finger protein 138 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC073349

  9. NM_001367574.1 → NP_001354503.1  zinc finger protein 138 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variant 13, encodes isoform 10.
    Source sequence(s)
    AC073349

  10. NM_001367575.1 → NP_001354504.1  zinc finger protein 138 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variant 12, encodes isoform 10.
    Source sequence(s)
    AC073349

  11. NM_001367576.1 → NP_001354505.1  zinc finger protein 138 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC073349

  12. NM_001367577.1 → NP_001354506.1  zinc finger protein 138 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC073349

  13. NM_006524.4 → NP_006515.3  zinc finger protein 138 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC073349
    Consensus CDS
    CCDS34645.2
    Related
    ENSP00000407262.2, ENST00000440155.6

RNA

  1. NR_073389.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon, and includes an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AC073349

  2. NR_073391.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) includes two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073349

  3. NR_160268.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349

  4. NR_160269.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349

  5. NR_160270.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349

  6. NR_160271.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073349

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    64794428..64860823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420816.1 → XP_047276772.1  zinc finger protein 138 isoform X6

    UniProtKB/TrEMBL
    C9JHF6

  2. XM_047420814.1 → XP_047276770.1  zinc finger protein 138 isoform X5

  3. XM_047420815.1 → XP_047276771.1  zinc finger protein 138 isoform X5

  4. XM_047420811.1 → XP_047276767.1  zinc finger protein 138 isoform X3

  5. XM_047420812.1 → XP_047276768.1  zinc finger protein 138 isoform X4

  6. XM_047420808.1 → XP_047276764.1  zinc finger protein 138 isoform X1

  7. XM_047420813.1 → XP_047276769.1  zinc finger protein 138 isoform X8

  8. XM_047420810.1 → XP_047276766.1  zinc finger protein 138 isoform X2

  9. XM_047420809.1 → XP_047276765.1  zinc finger protein 138 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    66001955..66067000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358955.1 → XP_054214930.1  zinc finger protein 138 isoform X11

  2. XM_054358967.1 → XP_054214942.1  zinc finger protein 138 isoform X6

    UniProtKB/TrEMBL
    C9JHF6

  3. XM_054358956.1 → XP_054214931.1  zinc finger protein 138 isoform X11

  4. XM_054358957.1 → XP_054214932.1  zinc finger protein 138 isoform X11

  5. XM_054358965.1 → XP_054214940.1  zinc finger protein 138 isoform X5

  6. XM_054358966.1 → XP_054214941.1  zinc finger protein 138 isoform X5

  7. XM_054358963.1 → XP_054214938.1  zinc finger protein 138 isoform X13

  8. XM_054358964.1 → XP_054214939.1  zinc finger protein 138 isoform X5

  9. XM_054358960.1 → XP_054214935.1  zinc finger protein 138 isoform X3

  10. XM_054358962.1 → XP_054214937.1  zinc finger protein 138 isoform X4

  11. XM_054358953.1 → XP_054214928.1  zinc finger protein 138 isoform X9

  12. XM_054358958.1 → XP_054214933.1  zinc finger protein 138 isoform X1

  13. XM_054358961.1 → XP_054214936.1  zinc finger protein 138 isoform X12

  14. XM_054358959.1 → XP_054214934.1  zinc finger protein 138 isoform X2

  15. XM_054358954.1 → XP_054214929.1  zinc finger protein 138 isoform X10

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52744.2 GenPept UniProtKB/Swiss-Prot:P52744

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