Ube2ql1 ubiquitin-conjugating enzyme E2Q family-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2ql1provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2Q family-like 1provided by MGI
Primary source: MGI:MGI:1924230
See related: Ensembl:ENSMUSG00000052981 AllianceGenome:MGI:1924230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 3110006E14Rik
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in bone; central nervous system; dorsal root ganglion; heart; and liver. Orthologous to human UBE2QL1 (ubiquitin conjugating enzyme E2 QL1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in frontal lobe adult (RPKM 43.4), cortex adult (RPKM 36.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B3- C1; 13 35.55 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (69850951..69888016, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (69702832..69739897, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2Q-like protein 1

Names: E2Q-like ubiquitin-conjugating enzyme 1

NP_001138634.1

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145162.1 → NP_001138634.1 ubiquitin-conjugating enzyme E2Q-like protein 1

Status: VALIDATED

Source sequence(s)

AC122371, BC049672, BC058543

Consensus CDS

CCDS49307.1

UniProtKB/TrEMBL

E9QMD2

Related

ENSMUSP00000070906.6, ENSMUST00000065118.7

Conserved Domains (1) summary

cd00195
Location:140 → 258

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...