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Mpped2 metallophosphoesterase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 77015, updated on 9-Aug-2024

Summary

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Official Symbol
Mpped2provided by MGI
Official Full Name
metallophosphoesterase domain containing 2provided by MGI
Primary source
MGI:MGI:1924265
See related
Ensembl:ENSMUSG00000016386 AllianceGenome:MGI:1924265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
239Fb; 2700082O15Rik
Summary
Predicted to enable manganese ion binding activity; phosphoric diester hydrolase activity; and purine ribonucleotide binding activity. Is expressed in axial skeleton; brain ventricular layer; head mesenchyme; and thyroid cartilage. Orthologous to human MPPED2 (metallophosphoesterase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 10.1), whole brain E14.5 (RPKM 7.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Mpped2 in Genome Data Viewer
Location:
2 E3; 2 55.8 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (106523526..106699684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (106693181..106868361)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05325 Neighboring gene predicted gene, 36544 Neighboring gene STARR-seq mESC enhancer starr_05326 Neighboring gene expressed sequence BB218582 Neighboring gene STARR-seq mESC enhancer starr_05327 Neighboring gene predicted gene, 29885 Neighboring gene RIKEN cDNA C130023O10 gene Neighboring gene predicted gene, 22813 Neighboring gene predicted gene, 54139 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 39902

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a novel gene adjacent to PAX6, revealing synteny conservation with functional significance. Kleinjan DA, et al. Mamm Genome, 2002 Feb. PMID 11889558
  2. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
  3. Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Moreau MX, et al. Development, 2021 Jul 15. PMID 34170322
  4. Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain. Lee DR, et al. Elife, 2022 Feb 17. PMID 35175194, Free PMC Article
  5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP binding ISO
Inferred from Sequence Orthology
more info
  
enables GMP binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
metallophosphoesterase MPPED2
Names
metallophosphoesterase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143683.2 → NP_001137155.1  metallophosphoesterase MPPED2 isoform a

    See identical proteins and their annotated locations for NP_001137155.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL512587, AL773516
    Consensus CDS
    CCDS50654.1
    UniProtKB/Swiss-Prot
    Q9CZJ0
    UniProtKB/TrEMBL
    B1APT1, B1APT2
    Related
    ENSMUSP00000106692.2, ENSMUST00000111063.8
    Conserved Domains (1) summary
    cd07379
    Location:59 → 271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

  2. NM_001356554.1 → NP_001343483.1  metallophosphoesterase MPPED2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AL512587, AL773516
    Consensus CDS
    CCDS50654.1
    UniProtKB/Swiss-Prot
    Q9CZJ0
    UniProtKB/TrEMBL
    B1APT1, B1APT2
    Conserved Domains (1) summary
    cd07379
    Location:59 → 271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

  3. NM_001356555.1 → NP_001343484.1  metallophosphoesterase MPPED2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AL512587, AL773516
    Conserved Domains (1) summary
    cd07379
    Location:72 → 145
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

  4. NM_029837.1 → NP_084113.1  metallophosphoesterase MPPED2 isoform a

    See identical proteins and their annotated locations for NP_084113.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AK012553, AK165186, AV230002
    Consensus CDS
    CCDS50654.1
    UniProtKB/Swiss-Prot
    Q9CZJ0
    UniProtKB/TrEMBL
    B1APT1, B1APT2
    Related
    ENSMUSP00000016530.8, ENSMUST00000016530.14
    Conserved Domains (1) summary
    cd07379
    Location:59 → 271
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    106523526..106699684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252204.1 → XP_030108064.1  metallophosphoesterase MPPED2 isoform X1

  2. XM_011239842.4 → XP_011238144.1  metallophosphoesterase MPPED2 isoform X3

    See identical proteins and their annotated locations for XP_011238144.1

    Conserved Domains (1) summary
    cd07379
    Location:72 → 145
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

  3. XM_030252205.2 → XP_030108065.1  metallophosphoesterase MPPED2 isoform X2

    UniProtKB/TrEMBL
    B1APT1
    Conserved Domains (1) summary
    cd07379
    Location:26 → 238
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain

  4. XM_006500394.5 → XP_006500457.1  metallophosphoesterase MPPED2 isoform X3

    See identical proteins and their annotated locations for XP_006500457.1

    Conserved Domains (1) summary
    cd07379
    Location:72 → 145
    MPP_239FB; Homo sapiens 239FB and related proteins, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZJ0.1 GenPept UniProtKB/Swiss-Prot:Q9CZJ0

Gene LinkOut

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