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Tmem181a transmembrane protein 181A [ Mus musculus (house mouse) ]

Gene ID: 77106, updated on 9-Aug-2024

Summary

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Official Symbol
Tmem181aprovided by MGI
Official Full Name
transmembrane protein 181Aprovided by MGI
Primary source
MGI:MGI:1924356
See related
Ensembl:ENSMUSG00000038141 AllianceGenome:MGI:1924356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr178; Tmem181; mKIAA1423; 5930418K15Rik
Summary
Predicted to enable toxic substance binding activity. Is expressed in several structures, including cardiovascular system; central nervous system; gut; reproductive system; and trachea. Orthologous to human TMEM181 (transmembrane protein 181). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 47.1), frontal lobe adult (RPKM 44.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem181a in Genome Data Viewer
Location:
17 A1; 17 3.85 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (6307001..6358589)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6256726..6308314)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene TUB like protein 4 Neighboring gene fibrillarin pseudogene Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_41716 Neighboring gene STARR-seq mESC enhancer starr_41717 Neighboring gene STARR-positive B cell enhancer mm9_chr17:6314045-6314346 Neighboring gene STARR-seq mESC enhancer starr_41718 Neighboring gene dynein light chain Tctex-type 1A Neighboring gene STARR-seq mESC enhancer starr_41719 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 2, pseudogene 1 Neighboring gene tubby like protein 4 pseudogene Neighboring gene fibrillarin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
  2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC182481

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables toxic substance binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
transmembrane protein 181

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033178.3 → NP_001028350.1  transmembrane protein 181 isoform 1

    See identical proteins and their annotated locations for NP_001028350.1

    Status: VALIDATED

    Source sequence(s)
    AC183097, AW825806, BE862876, BQ832419, CD539539, CF747635, CJ168748
    Consensus CDS
    CCDS37425.1
    UniProtKB/TrEMBL
    B2RVR2, Q3U3W2
    Related
    ENSMUSP00000086333.5, ENSMUST00000088940.6
    Conserved Domains (1) summary
    pfam06664
    Location:127 → 422
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  2. NM_001357884.1 → NP_001344813.1  transmembrane protein 181 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092481, AC183097, CF747635
    Consensus CDS
    CCDS88983.1
    UniProtKB/TrEMBL
    A0A338P7C9, B2RVR2
    Related
    ENSMUSP00000156382.2, ENSMUST00000232383.2
    Conserved Domains (1) summary
    pfam06664
    Location:168 → 463
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    6307001..6358589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250141.1 → XP_030106001.1  transmembrane protein 181 isoform X1

    UniProtKB/TrEMBL
    B2RVR2
    Conserved Domains (1) summary
    pfam06664
    Location:168 → 463
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  2. XM_030250142.1 → XP_030106002.1  transmembrane protein 181 isoform X2

    UniProtKB/TrEMBL
    B2RVR2
    Conserved Domains (1) summary
    pfam06664
    Location:168 → 463
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  3. XM_030250144.2 → XP_030106004.1  transmembrane protein 181 isoform X3

    Conserved Domains (1) summary
    pfam06664
    Location:1 → 263
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RNA

  1. XR_876333.2 RNA Sequence

  2. XR_003952212.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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