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Adgrf1 adhesion G protein-coupled receptor F1 [ Mus musculus (house mouse) ]

Gene ID: 77596, updated on 9-Dec-2024

Summary

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Official Symbol
Adgrf1provided by MGI
Official Full Name
adhesion G protein-coupled receptor F1provided by MGI
Primary source
MGI:MGI:1924846
See related
Ensembl:ENSMUSG00000041293 AllianceGenome:MGI:1924846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr110; KPG_009; 5031409J19Rik
Summary
Enables G protein-coupled receptor activity. Acts upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Located in plasma membrane. Is expressed in adrenal gland; liver; and metanephros. Orthologous to human ADGRF1 (adhesion G protein-coupled receptor F1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in liver E18 (RPKM 3.1), liver adult (RPKM 1.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Adgrf1 in Genome Data Viewer
Location:
17 B3; 17 19.71 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43581174..43636767)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43270283..43325876)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130008D07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:43369751-43370032 Neighboring gene predicted gene, 54007 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43402088-43402388 Neighboring gene STARR-seq mESC enhancer starr_42590 Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene predicted gene, 25135 Neighboring gene STARR-seq mESC enhancer starr_42593 Neighboring gene STARR-seq mESC enhancer starr_42594 Neighboring gene meprin 1 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation. Banerjee S, et al. J Neuroinflammation, 2023 Aug 14. PMID 37580715, Free PMC Article
  2. Interaction between GPR110 (ADGRF1) and tight junction protein occludin implicated in blood-brain barrier permeability. Huang BX, et al. iScience, 2023 Apr 21. PMID 37123219, Free PMC Article
  3. Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury. Kwon HS, et al. Int J Mol Sci, 2023 Mar 10. PMID 36982411, Free PMC Article
  4. Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis. Zhang M, et al. Br J Nutr, 2023 Nov 28. PMID 36946032
  5. GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice. Chen H, et al. J Neuroinflammation, 2021 Jul 17. PMID 34273979, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
    Title: Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
  2. Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1).
    Title: Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1).
  3. Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation.
    Title: Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation.
  4. Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.
    Title: Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.
  5. GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice.
    Title: GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice.
  6. Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.
    Title: Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.
  7. Study demonstrated orphan G-protein coupled receptor 110 (GPR110, ADGRF1) as the synaptamide receptor, mediating synaptamide-induced bioactivity in a cAMP-dependent manner.
    Title: Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in energy reserve metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adhesion G-protein coupled receptor F1
Names
G protein coupled receptor Gpr110
G-protein coupled receptor 110
internal gene name of KIRIN laboratory:M5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133776.3 → NP_598537.2  adhesion G-protein coupled receptor F1 precursor

    See identical proteins and their annotated locations for NP_598537.2

    Status: VALIDATED

    Source sequence(s)
    CT025700
    Consensus CDS
    CCDS28795.1
    UniProtKB/Swiss-Prot
    B0V2Q5, Q8BMV8, Q8VEC3
    Related
    ENSMUSP00000049380.6, ENSMUST00000047399.6
    Conserved Domains (4) summary
    smart00303
    Location:530 → 571
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:584 → 607
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01390
    Location:153 → 240
    SEA; SEA domain
    cl28897
    Location:584 → 847
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    43581174..43636767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525120.4 → XP_006525183.1  adhesion G-protein coupled receptor F1 isoform X1

    Conserved Domains (4) summary
    smart00303
    Location:549 → 590
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:603 → 626
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01390
    Location:172 → 258
    SEA; SEA domain
    cl28897
    Location:603 → 866
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006525121.4 → XP_006525184.1  adhesion G-protein coupled receptor F1 isoform X2

    Conserved Domains (4) summary
    smart00303
    Location:548 → 589
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:602 → 625
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01390
    Location:171 → 257
    SEA; SEA domain
    cl28897
    Location:602 → 865
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_876591.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEC3.2 GenPept UniProtKB/Swiss-Prot:Q8VEC3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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