zdhhc15b zinc finger DHHC-type palmitoyltransferase 15b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zdhhc15bprovided by ZNC
Official Full Name: zinc finger DHHC-type palmitoyltransferase 15bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061110-106
See related: Ensembl:ENSDARG00000071872 AllianceGenome:ZFIN:ZDB-GENE-061110-106
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc02b12; zdhhc15; wu:fc02b12; zgc:152683
Summary: Enables protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in peptidyl-L-cysteine S-palmitoylation. Acts upstream of or within dopaminergic neuron differentiation; forebrain development; and protein palmitoleylation. Is integral component of Golgi membrane. Is expressed in diencephalon; forebrain; head; midbrain; and telencephalon. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 91. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (10954359..10974650)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (10648345..10668636)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structure determined; active site resides at the membrane-cytosol interface; acyl chain binds in a cavity formed by the transmembrane domain; propose a mechanism for acyl chain-length selectivity in DHHC enzymes on the basis of cavity mutants with preferences for shorter and longer acyl chains
Title: Fatty acyl recognition and transfer by an integral membrane S-acyltransferase.
Our results reveal that zdhhc15b controls DA neuronal fate decisions by regulating differentiation but not progenitor cell proliferation or DA neuronal survival
Title: Zdhhc15b Regulates Differentiation of Diencephalic Dopaminergic Neurons in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-L-cysteine S-palmitoylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein palmitoleylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC15B

Names: acyltransferase ZDHHC15B; palmitoyltransferase ZDHHC15; zinc finger DHHC domain-containing protein 15B; zinc finger DHHC-type containing 15b; zinc finger, DHHC domain containing 15; zinc finger, DHHC domain containing 15b

NP_001071249.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.