Coro7 coronin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coro7provided by MGI
Official Full Name: coronin 7provided by MGI
Primary source: MGI:MGI:1926135
See related: Ensembl:ENSMUSG00000039637 AllianceGenome:MGI:1926135
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610011B16Rik
Summary: Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including Golgi organization; actin filament organization; and establishment of cell polarity. Located in Golgi apparatus. Is integral component of membrane. Is expressed in hemolymphoid system; nervous system; neural retina; and small intestine. Orthologous to several human genes including CORO7-PAM16 (CORO7-PAM16 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 73.3), spleen adult (RPKM 53.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.45 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (4444748..4497584, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4626884..4679720, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We conclude that CRN7 spatiotemporally influences F-actin organization and Golgi integrity in a Cdc42- and N-WASP-dependent manner.
Title: Novel Coronin7 interactions with Cdc42 and N-WASP regulate actin organization and Golgi morphology.
profiling of Coro7 mRNA expression revealed it is highly expressed in appetite and energy balance regulating regions of the brain; food deprivation downregulates hypothalamic Coro7 mRNA; conclude that coronin 7 is involved in the regulation of energy homeostasis and this role stems, to some degree, from the effect on feeding for calories and
Title: Implication of coronin 7 in body weight regulation in humans, mice and flies.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16Mit180 (e-PCR), detects polymorphism
- UniSTS:127812

AW048373 (e-PCR)
- UniSTS:165972

22.MMHAP26FLH1.seq (e-PCR)
- UniSTS:123563

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coronin-7

Names: 70 kDa WD repeat tumor rejection antigen homolog; crn7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030205.4 → NP_084481.3 coronin-7

See identical proteins and their annotated locations for NP_084481.3

Status: PROVISIONAL

Source sequence(s)

BC061006

Consensus CDS

CCDS37242.1

UniProtKB/Swiss-Prot

Q3UDJ4, Q6P8Y8, Q8C9V7, Q9D2V7

Related

ENSMUSP00000048489.7, ENSMUST00000038552.13

Conserved Domains (4) summary

pfam08953
Location:467 → 524

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:805 → 849

WD40_4; Type of WD40 repeat

sd00039
Location:545 → 589

7WD40; WD40 repeat [structural motif]

cl02567
Location:543 → 665

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...