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Fbxo34 F-box protein 34 [ Mus musculus (house mouse) ]

Gene ID: 78938, updated on 13-Jan-2025

Summary

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Official Symbol
Fbxo34provided by MGI
Official Full Name
F-box protein 34provided by MGI
Primary source
MGI:MGI:1926188
See related
Ensembl:ENSMUSG00000037536 AllianceGenome:MGI:1926188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900057B08Rik; 5830426G16Rik
Summary
Is expressed in liver. Orthologous to human FBXO34 (F-box protein 34). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in testis adult (RPKM 13.2), liver E14.5 (RPKM 10.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo34 in Genome Data Viewer
Location:
14 C1; 14 24.6 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47709992..47769419)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47472533..47531962)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DLG associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E606 Neighboring gene ribosomal protein S15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36580 Neighboring gene predicted gene, 35166 Neighboring gene autophagy related 14 Neighboring gene STARR-positive B cell enhancer ABC_E9894 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  2. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
  3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
F-box only protein 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146085.1 → NP_001139557.1  F-box only protein 34 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes two alternate segments which result in the use of a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform 2) which is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC123665, AK020018, CB575943
    Consensus CDS
    CCDS49471.1
    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Related
    ENSMUSP00000131708.2, ENSMUST00000163324.8
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  2. NM_001146086.1 → NP_001139558.1  F-box only protein 34 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate segment which results in the use of a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same protein (isoform 2) which is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK020018, BB703607, BC049155
    Consensus CDS
    CCDS49471.1
    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Related
    ENSMUSP00000132271.2, ENSMUST00000168833.9
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  3. NM_030236.3 → NP_084512.2  F-box only protein 34 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK020018, BB703607, BC049155
    Consensus CDS
    CCDS26988.1
    UniProtKB/TrEMBL
    E9QM55, Q3TAU3
    Related
    ENSMUSP00000044675.8, ENSMUST00000043112.9
    Conserved Domains (1) summary
    cl45894
    Location:610 → 657
    F-box_SF; F-box domain superfamily

RNA

  1. NR_027414.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains four alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK013711, AK020018, BB703607, BC049155
    Related
    ENSMUST00000228019.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    47709992..47769419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519723.5 → XP_006519786.2  F-box only protein 34 isoform X1

    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam12937
    Location:711 → 745
    F-box-like

  2. XM_006519710.2 → XP_006519773.1  F-box only protein 34 isoform X2

    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam12937
    Location:579 → 613
    F-box-like

  3. XM_036158918.1 → XP_036014811.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  4. XM_030248097.2 → XP_030103957.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  5. XM_017316225.3 → XP_017171714.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  6. XM_006519722.1 → XP_006519785.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  7. XM_036158916.1 → XP_036014809.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  8. XM_006519713.2 → XP_006519776.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Related
    ENSMUSP00000093634.3, ENSMUST00000095941.9
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  9. XM_036158919.1 → XP_036014812.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  10. XM_006519717.3 → XP_006519780.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  11. XM_006519718.4 → XP_006519781.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  12. XM_006519714.1 → XP_006519777.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Related
    ENSMUSP00000130036.2, ENSMUST00000165714.2
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  13. XM_006519720.1 → XP_006519783.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  14. XM_006519712.5 → XP_006519775.1  F-box only protein 34 isoform X2

    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam12937
    Location:579 → 613
    F-box-like

  15. XM_006519719.2 → XP_006519782.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain

  16. XM_036158917.1 → XP_036014810.1  F-box only protein 34 isoform X3

    UniProtKB/Swiss-Prot
    Q80XI1, Q9D290
    UniProtKB/TrEMBL
    Q3TAU3
    Conserved Domains (1) summary
    pfam00646
    Location:561 → 593
    F-box; F-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XI1.2 GenPept UniProtKB/Swiss-Prot:Q80XI1

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