cyp11c1 cytochrome P450, family 11, subfamily C, polypeptide 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cyp11c1provided by ZNC
Official Full Name: cytochrome P450, family 11, subfamily C, polypeptide 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-070828-1
See related: Ensembl:ENSDARG00000042014 AllianceGenome:ZFIN:ZDB-GENE-070828-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cyp11b2
Summary: Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Acts upstream of or within cortisol metabolic process; male gonad development; and mating behavior. Predicted to be active in mitochondrial inner membrane. Is expressed in Leydig cell; brain; and pleuroperitoneal region. Used to study congenital adrenal hyperplasia. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (54459131..54473754, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (54639247..54653906, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction.
Title: Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction.
Data show that cytochrome P450 enzymes Cyp17-I, Cyp11c1, Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein Foxl2a were detected both in the testis and ovary.
Title: Localization of steroidogenic enzymes and Foxl2a in the gonads of mature zebrafish (Danio rerio).

Submit: New GeneRIF Correction

General gene information

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Markers

G48086 (e-PCR)
- UniSTS:108850

G41715 (e-PCR)
- UniSTS:71500

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables steroid 11-beta-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to peptide hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortisol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cortisol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
involved_in glucocorticoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurotransmitter transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 11C1; cytochrome P450, family 11, subfamily C, polypeptide 1

Names: cyp11b; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P45011B

NP_001073673.1

EC 1.14.15.4

XP_017206857.1

EC 1.14.15.4

XP_017206858.1

EC 1.14.15.4

XP_017206859.1

EC 1.14.15.4

XP_021322434.1

EC 1.14.15.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080204.1 → NP_001073673.1 cytochrome P450 11C1

See identical proteins and their annotated locations for NP_001073673.1

Status: PROVISIONAL

Source sequence(s)

DQ650710

UniProtKB/TrEMBL

A0A8M1NCP3, A1XRK1

Related

ENSDARP00000150599.1, ENSDART00000185978.1

Conserved Domains (1) summary

pfam00067
Location:43 → 511

p450; Cytochrome P450

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

54459131..54473754 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017351368.2 → XP_017206857.1 cytochrome P450, family 11, subfamily C, polypeptide 1 isoform X1

UniProtKB/TrEMBL

A0A8M6YV96
XM_017351369.2 → XP_017206858.1 cytochrome P450, family 11, subfamily C, polypeptide 1 isoform X1

UniProtKB/TrEMBL

A0A8M6YV96
XM_017351370.2 → XP_017206859.1 cytochrome P450, family 11, subfamily C, polypeptide 1 isoform X1

UniProtKB/TrEMBL

A0A8M6YV96

Related

ENSDARP00000061571.5, ENSDART00000061572.6
XM_021466759.1 → XP_021322434.1 cytochrome P450, family 11, subfamily C, polypeptide 1 isoform X2

UniProtKB/TrEMBL

A0A8M9PD87

Conserved Domains (2) summary

pfam00067
Location:225 → 693

p450; Cytochrome P450

pfam05835
Location:1 → 125

Synaphin; Synaphin protein