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astn1 astrotactin 1 [ Danio rerio (zebrafish) ]

Gene ID: 791157, updated on 9-Dec-2024

Summary

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Official Symbol
astn1provided by ZNC
Official Full Name
astrotactin 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-050320-140
See related
Ensembl:ENSDARG00000068323 AllianceGenome:ZFIN:ZDB-GENE-050320-140
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:113405; zgc:158703
Summary
Predicted to be involved in neuron cell-cell adhesion and neuron migration. Predicted to be active in endosome and membrane. Used to study schizophrenia. Orthologous to human ASTN1 (astrotactin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See astn1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (34572889..34982401)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (34589679..34999941)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487979 Neighboring gene bone morphogenetic protein/retinoic acid inducible neural-specific 2 Neighboring gene uncharacterized LOC137487981 Neighboring gene uncharacterized LOC137487476 Neighboring gene pappalysin 2 Neighboring gene COP1 E3 ubiquitin ligase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Giousoh A, et al. Gene Expr Patterns, 2015 May-Jul. PMID 25981450
  2. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC113405

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuron migration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
astrotactin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    34572889..34982401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003197882.6 → XP_003197930.4  astrotactin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8M1RIG4

  2. XM_021467632.2 → XP_021323307.1  astrotactin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P116
    Conserved Domains (3) summary
    smart00457
    Location:820 → 1007
    MACPF; membrane-attack complex / perforin
    cd00063
    Location:1116 → 1158
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam14670
    Location:668 → 715
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_017351897.3 → XP_017207386.1  astrotactin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8M6Z1V4, F1Q5X4
    Related
    ENSDARP00000071684.5, ENSDART00000077216.6

  4. XM_017351899.3 → XP_017207388.1  astrotactin-1 isoform X4

    UniProtKB/TrEMBL
    A0A8M6YVX7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013561.1: Suppressed sequence

    Description
    NM_001013561.1: This RefSeq was temporarily suppressed because the CDS was partial.

  2. NM_001080639.1: Suppressed sequence

    Description
    NM_001080639.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: ASTN1 (GeneID:460).
Nucleotide Protein Strain
Heading Accession and Version

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