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dachd dachshund d [ Danio rerio (zebrafish) ]

Gene ID: 791191, updated on 2-Nov-2024

Summary

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Official Symbol
dachdprovided by ZNC
Official Full Name
dachshund dprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070427-2
See related
Ensembl:ENSDARG00000069440 AllianceGenome:ZFIN:ZDB-GENE-070427-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:158869; si:ch211-176j8.3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within glomerular filtration. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including immature eye; nervous system; neural tube; otic vesicle; and pronephros. Orthologous to human DACH1 (dachshund family transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See dachd in Genome Data Viewer
Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (30890549..31065163)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (31079803..31254411)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene Kruppel like factor 5b Neighboring gene uncharacterized LOC101887159 Neighboring gene uncharacterized LOC137496481 Neighboring gene G protein-coupled receptor 18 Neighboring gene G protein-coupled receptor 183a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease. Ahmed I, et al. Comput Struct Biotechnol J, 2023. PMID 36659918, Free PMC Article
  2. The transcription factor Dach1 is essential for podocyte function. Endlich N, et al. J Cell Mol Med, 2018 May. PMID 29498212, Free PMC Article
  3. Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo. Hollway GE, et al. Dev Cell, 2007 Feb. PMID 17276339
  4. Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. Yang L, et al. J Diabetes Investig, 2021 May. PMID 33449448, Free PMC Article
  5. Dachshund homologues play a conserved role in islet cell development. Kalousova A, et al. Dev Biol, 2010 Dec 15. PMID 20869363, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glomerular filtration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dachshund d

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080673.1 → NP_001074142.1  dachshund d

    See identical proteins and their annotated locations for NP_001074142.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129504
    UniProtKB/TrEMBL
    A1L2G2
    Related
    ENSDARP00000091844.4, ENSDART00000101070.5
    Conserved Domains (2) summary
    pfam02437
    Location:88 → 188
    Ski_Sno; SKI/SNO/DAC family
    cl20817
    Location:478 → 531
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    30890549..31065163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167750.5 → XP_005167807.1  dachshund d isoform X2

    UniProtKB/TrEMBL
    A0A8M2BF69
    Conserved Domains (2) summary
    pfam02437
    Location:88 → 188
    Ski_Sno; SKI/SNO/DAC family
    cl20817
    Location:478 → 531
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_005167749.5 → XP_005167806.1  dachshund d isoform X1

    UniProtKB/TrEMBL
    A0A8M2BF65
    Conserved Domains (2) summary
    pfam02437
    Location:88 → 188
    Ski_Sno; SKI/SNO/DAC family
    cl20817
    Location:477 → 530
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_068223479.1 → XP_068079580.1  dachshund d isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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