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crym crystallin, mu [ Danio rerio (zebrafish) ]

Gene ID: 791205, updated on 2-Nov-2024

Summary

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Official Symbol
crymprovided by ZNC
Official Full Name
crystallin, muprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-1782
See related
Ensembl:ENSDARG00000062817 AllianceGenome:ZFIN:ZDB-GENE-070112-1782
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:158843
Summary
Predicted to enable thyroid hormone binding activity. Predicted to be involved in thyroid hormone metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 40. Orthologous to human CRYM (crystallin mu). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See crym in Genome Data Viewer
Location:
chromosome: 12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10448180..10462503)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10410356..10424663)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase core protein 2b Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5) Neighboring gene Rac family small GTPase 1a Neighboring gene Sad1 and UNC84 domain containing 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Varshney GK, et al. Genome Res, 2015 Jul. PMID 26048245, Free PMC Article
  2. Lens defects in Astyanax mexicanus Cavefish: evolution of crystallins and a role for alphaA-crystallin. Hinaux H, et al. Dev Neurobiol, 2015 May. PMID 25348293
  3. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables thiomorpholine-carboxylate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables thyroid hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in thyroid hormone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ketimine reductase mu-crystallin
NP_001074156.1
XP_068080751.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080687.1 → NP_001074156.1  ketimine reductase mu-crystallin

    See identical proteins and their annotated locations for NP_001074156.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129485
    UniProtKB/TrEMBL
    A1L2E5
    Related
    ENSDARP00000126995.1, ENSDART00000152824.2
    Conserved Domains (2) summary
    pfam02423
    Location:12 → 310
    OCD_Mu_crystall; Ornithine cyclodeaminase/mu-crystallin family
    cl21454
    Location:6 → 311
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    10448180..10462503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224650.1 → XP_068080751.1  ketimine reductase mu-crystallin isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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