DHRS11 dehydrogenase/reductase 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DHRS11provided by HGNC
Official Full Name: dehydrogenase/reductase 11provided by HGNC
Primary source: HGNC:HGNC:28639
See related: Ensembl:ENSG00000278535 MIM:616159; AllianceGenome:HGNC:28639
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARPG836; SDR24C1; spDHRS11
Summary: Enables 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in duodenum (RPKM 115.7), small intestine (RPKM 99.1) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (36591879..36600804)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (37578223..37587148)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (34948309..34957233)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids.
Title: Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C(19)-steroids.
The recombinant protein (DHRS11) efficiently catalyzed the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5alpha-androstanes into their 17beta-hydroxyl metabolites with NADPH as a coenzyme.
Title: Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78009 (e-PCR)
- UniSTS:53804

STS-T49181 (e-PCR)
- UniSTS:27559

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables 17-beta-ketosteroid reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-keto sterol reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in estrogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in steroid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dehydrogenase/reductase SDR family member 11

Names: 17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; dehydrogenase/reductase (SDR family) member 11; estradiol 17-beta-dehydrogenase; short-chain dehydrogenase/reductase family 24C member 1

NP_077284.2

EC 1.1.1.270

EC 1.1.1.62

XP_005257715.1

EC 1.1.1.270

EC 1.1.1.62

XP_011523535.1

EC 1.1.1.270

EC 1.1.1.62

XP_047292688.1

EC 1.1.1.270

EC 1.1.1.62

XP_054173159.1

EC 1.1.1.270

EC 1.1.1.62

XP_054173160.1

EC 1.1.1.270

EC 1.1.1.62

XP_054173161.1

EC 1.1.1.270

EC 1.1.1.62

XP_054185307.1

EC 1.1.1.270

EC 1.1.1.62

XP_054185308.1

EC 1.1.1.270

EC 1.1.1.62

XP_054185309.1

EC 1.1.1.270

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024308.4 → NP_077284.2 dehydrogenase/reductase SDR family member 11 precursor

See identical proteins and their annotated locations for NP_077284.2

Status: VALIDATED

Source sequence(s)

AY358712, BG037061

Consensus CDS

CCDS11315.2

UniProtKB/Swiss-Prot

A0A0U5BLD0, B2RDZ3, Q6UWP2, Q9BUC7, Q9H674

Related

ENSP00000482704.1, ENST00000618403.5

Conserved Domains (1) summary

cd05343
Location:6 → 256

Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

36591879..36600804

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005257658.4 → XP_005257715.1 dehydrogenase/reductase SDR family member 11 isoform X1

See identical proteins and their annotated locations for XP_005257715.1

UniProtKB/Swiss-Prot

Q6UWP2

Conserved Domains (1) summary

cd05343
Location:6 → 225

Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs
XM_011525233.3 → XP_011523535.1 dehydrogenase/reductase SDR family member 11 isoform X2

See identical proteins and their annotated locations for XP_011523535.1

Conserved Domains (2) summary

COG4221
Location:6 → 189

YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]

cl21454
Location:6 → 186

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_047436732.1 → XP_047292688.1 dehydrogenase/reductase SDR family member 11 isoform X3

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

827374..836298

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329332.1 → XP_054185307.1 dehydrogenase/reductase SDR family member 11 isoform X1
XM_054329333.1 → XP_054185308.1 dehydrogenase/reductase SDR family member 11 isoform X2
XM_054329334.1 → XP_054185309.1 dehydrogenase/reductase SDR family member 11 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

37578223..37587148

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054317184.1 → XP_054173159.1 dehydrogenase/reductase SDR family member 11 isoform X1
XM_054317185.1 → XP_054173160.1 dehydrogenase/reductase SDR family member 11 isoform X2
XM_054317186.1 → XP_054173161.1 dehydrogenase/reductase SDR family member 11 isoform X3