ptrh2 peptidyl-tRNA hydrolase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptrh2provided by ZNC
Official Full Name: peptidyl-tRNA hydrolase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-163
See related: Ensembl:ENSDARG00000077339 AllianceGenome:ZFIN:ZDB-GENE-050522-163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fj09f02; zgc:109954
Summary: Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be involved in negative regulation of anoikis and positive regulation of anoikis. Predicted to be located in membrane. Predicted to be active in cytosol. Orthologous to human PTRH2 (peptidyl-tRNA hydrolase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (28306747..28309313)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (28420122..28422688)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aminoacyl-tRNA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminoacyl-tRNA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of anoikis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of anoikis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidyl-tRNA hydrolase 2, mitochondrial

NP_001018371.2

EC 3.1.1.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020535.2 → NP_001018371.2 peptidyl-tRNA hydrolase 2, mitochondrial

Status: VALIDATED

Source sequence(s)

CR392341

UniProtKB/TrEMBL

A0A8M1N623, F1Q6B2

Related

ENSDARP00000118511.1, ENSDART00000142016.2

Conserved Domains (1) summary

cd02430
Location:62 → 176

PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...