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hip1 huntingtin interacting protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 793823, updated on 14-Nov-2024

Summary

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Official Symbol
hip1provided by ZNC
Official Full Name
huntingtin interacting protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-010328-15
See related
Ensembl:ENSDARG00000062972 AllianceGenome:ZFIN:ZDB-GENE-010328-15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb98d04; wu:fb98d04
Summary
Predicted to enable several functions, including anion binding activity; clathrin adaptor activity; and clathrin light chain binding activity. Acts upstream of or within chordate embryonic development and response to yeast. Predicted to be located in cytoplasm. Predicted to be active in clathrin-coated vesicle; cortical actin cytoskeleton; and presynapse. Orthologous to human HIP1 (huntingtin interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See hip1 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (16935390..17024779, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (17000111..17088823, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1 Neighboring gene yippee-like 2b Neighboring gene perilipin 2 Neighboring gene Ig-like domain-containing protein Neighboring gene CLPTM1 regulator of GABA type A receptor forward trafficking

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish gene knockdowns imply roles for human YWHAG in infantile spasms and cardiomegaly. Komoike Y, et al. Genesis, 2010 Apr. PMID 20146355
  2. Expression and phylogeny of claudins in vertebrate primordia. Kollmar R, et al. Proc Natl Acad Sci U S A, 2001 Aug 28. PMID 11517306, Free PMC Article
  3. MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function. Lu J, et al. Oncogene, 2018 Jul. PMID 29662197, Free PMC Article
  4. Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study. Wang YC, et al. BMC Syst Biol, 2013 Aug 16. PMID 23947337, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to yeast IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
huntingtin-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166205.2 → NP_001159677.1  huntingtin-interacting protein 1

    See identical proteins and their annotated locations for NP_001159677.1

    Status: PROVISIONAL

    Source sequence(s)
    AB494966
    UniProtKB/TrEMBL
    C9K4U5
    Related
    ENSDARP00000127621.1, ENSDART00000154719.3
    Conserved Domains (5) summary
    smart00307
    Location:836 → 1034
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:40 → 308
    ANTH; ANTH domain
    pfam15619
    Location:378 → 557
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    pfam16515
    Location:483 → 581
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    cl23720
    Location:377 → 489
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    16935390..17024779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157432.5 → XP_005157489.1  huntingtin-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B480, F1R6L2
    Related
    ENSDARP00000013812.10, ENSDART00000014465.10
    Conserved Domains (5) summary
    smart00307
    Location:836 → 1034
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:40 → 308
    ANTH; ANTH domain
    pfam16515
    Location:483 → 581
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    pfam17045
    Location:383 → 642
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:377 → 489
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. XM_005157433.5 → XP_005157490.1  huntingtin-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B3I8
    Conserved Domains (5) summary
    smart00307
    Location:802 → 1000
    ILWEQ; I/LWEQ domain
    pfam07651
    Location:7 → 274
    ANTH; ANTH domain
    pfam16515
    Location:449 → 547
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    pfam17045
    Location:349 → 608
    CEP63; Centrosomal protein of 63 kDa
    cl23720
    Location:343 → 455
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_009291565.4 → XP_009289840.1  huntingtin-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3ASL4
    Conserved Domains (5) summary
    smart00307
    Location:802 → 1000
    ILWEQ; I/LWEQ domain
    pfam00261
    Location:385 → 592
    Tropomyosin; Tropomyosin
    pfam07651
    Location:40 → 308
    ANTH; ANTH domain
    pfam16515
    Location:483 → 595
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    cl23720
    Location:377 → 489
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394943.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    60161..148019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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