scn8ab sodium channel, voltage gated, type VIII, alpha subunit b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scn8abprovided by ZNC
Official Full Name: sodium channel, voltage gated, type VIII, alpha subunit bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060906-2
See related: Ensembl:ENSDARG00000018032 AllianceGenome:ZFIN:ZDB-GENE-060906-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable voltage-gated sodium channel activity. Acts upstream of or within axon regeneration and fin regeneration. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in bone tissue; heart; and nervous system. Human ortholog(s) of this gene implicated in benign familial infantile seizures 5 and developmental and epileptic encephalopathy 13. Orthologous to human SCN8A (sodium voltage-gated channel alpha subunit 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (39388150..39489196, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (39390614..39491680, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fk52c03.x1 (e-PCR)
- UniSTS:201121

fj25e10.y1 (e-PCR)
- UniSTS:198891

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane depolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuronal action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated sodium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium channel, voltage gated, type VIII, alpha subunit b

Names: sodium channel, voltage-gated, type VIII, alpha b; zscn1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045183.1 → NP_001038648.1 sodium channel, voltage gated, type VIII, alpha subunit b

See identical proteins and their annotated locations for NP_001038648.1

Status: PROVISIONAL

Source sequence(s)

DQ149509

UniProtKB/TrEMBL

Q20JQ3

Related

ENSDARP00000013108.7, ENSDART00000022761.8

Conserved Domains (5) summary

cd13433
Location:1440 → 1492

Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits

pfam00520
Location:1190 → 1448

Ion_trans; Ion transport protein

pfam06512
Location:964 → 1167

Na_trans_assoc; Sodium ion transport-associated

pfam11933
Location:503 → 591

Na_trans_cytopl; Cytoplasmic domain of voltage-gated Na+ ion channel

cl21478
Location:391 → 452

ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

39388150..39489196 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068221810.1 → XP_068077911.1 sodium channel, voltage gated, type VIII, alpha subunit b isoform X4
XM_068221807.1 → XP_068077908.1 sodium channel, voltage gated, type VIII, alpha subunit b isoform X2
XM_068221809.1 → XP_068077910.1 sodium channel, voltage gated, type VIII, alpha subunit b isoform X3
XM_068221806.1 → XP_068077907.1 sodium channel, voltage gated, type VIII, alpha subunit b isoform X1
XM_068221808.1 → XP_068077909.1 sodium channel, voltage gated, type VIII, alpha subunit b isoform X1