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Aldoart2 aldolase 1 A, retrogene 2 [ Mus musculus (house mouse) ]

Gene ID: 79459, updated on 11-Apr-2024

Summary

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Official Symbol
Aldoart2provided by MGI
Official Full Name
aldolase 1 A, retrogene 2provided by MGI
Primary source
MGI:MGI:1931052
See related
Ensembl:ENSMUSG00000063129 AllianceGenome:MGI:1931052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aldo1-ps1; Aldoa-ps1; 4933425L11Rik
Summary
Predicted to enable several functions, including fructose binding activity; fructose-bisphosphate aldolase activity; and identical protein binding activity. Predicted to be involved in several processes, including binding activity of sperm to zona pellucida; fructose 1,6-bisphosphate metabolic process; and purine ribonucleotide metabolic process. Predicted to be located in actin cytoskeleton; extracellular exosome; and sperm head. Predicted to be active in cytosol. Is expressed in alimentary system; eye; nervous system; and trunk. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Aldoart2 in Genome Data Viewer
Location:
12 C1; 12 24.04 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55611990..55613681)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55565205..55566896)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E473 Neighboring gene STARR-positive B cell enhancer ABC_E7134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56600132-56600241 Neighboring gene STARR-seq mESC enhancer starr_32192 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Neighboring gene predicted gene, 36634 Neighboring gene STARR-seq mESC enhancer starr_32194 Neighboring gene Ral GTPase activating protein, alpha subunit 1 Neighboring gene insulinoma-associated 2 Neighboring gene STARR-seq mESC enhancer starr_32196 Neighboring gene STARR-seq mESC enhancer starr_32197 Neighboring gene STARR-positive B cell enhancer ABC_E11776

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of Aldolase A pseudogenes in mice: multiple origins, subsequent duplications, and heterogeneity of evolutionary rates. Cortinas MN, et al. Mol Biol Evol, 2001 Sep. PMID 11504845
  2. Three male germline-specific aldolase A isozymes are generated by alternative splicing and retrotransposition. Vemuganti SA, et al. Dev Biol, 2007 Sep 1. PMID 17659271
  3. Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Tateno M, et al. Cancer Res, 2001 Feb 1. PMID 11221845
  4. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • 4933425L11Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fructose-bisphosphate aldolase A-like
Names
aldolase A retroprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277340.1 → NP_001264269.1  fructose-bisphosphate aldolase A-like

    See identical proteins and their annotated locations for NP_001264269.1

    Status: VALIDATED

    Source sequence(s)
    AC158398, AK016920
    Consensus CDS
    CCDS70384.1
    UniProtKB/TrEMBL
    A6ZI47, Q6NY00
    Related
    ENSMUSP00000079022.2, ENSMUST00000080123.2
    Conserved Domains (1) summary
    pfam00274
    Location:15 → 364
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55611990..55613681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_005196.1: Suppressed sequence

    Description
    NG_005196.1: This RefSeq was permanently suppressed because it is now thought that this gene is a transcribed pseudogene.
Nucleotide Protein Strain
Heading Accession and Version

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