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aplp2 amyloid beta (A4) precursor-like protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 796801, updated on 4-Jan-2025

Summary

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Official Symbol
aplp2provided by ZNC
Official Full Name
amyloid beta (A4) precursor-like protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-061009-28
See related
Ensembl:ENSDARG00000054864 AllianceGenome:ZFIN:ZDB-GENE-061009-28
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fk52a05; wu:fk52a05; si:dkey-11k4.3
Summary
Predicted to enable heparin binding activity; serine-type endopeptidase inhibitor activity; and transition metal ion binding activity. Predicted to be involved in axonogenesis and central nervous system development. Predicted to be located in endomembrane system and membrane. Is expressed in several structures, including heart; liver; nervous system; pleuroperitoneal region; and solid lens vesicle. Orthologous to human APLP2 (amyloid beta precursor like protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See aplp2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (44364530..44526895, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (44371076..44533516, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene si:ch211-151h10.2 Neighboring gene PR domain containing 10 Neighboring gene ST14 transmembrane serine protease matriptase a Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish. Banote RK, et al. Sci Rep, 2020 Jun 23. PMID 32576936, Free PMC Article
  2. Developmental origins of neurotransmitter and transcriptome alterations in adult female zebrafish exposed to atrazine during embryogenesis. Wirbisky SE, et al. Toxicology, 2015 Jul 3. PMID 25929836, Free PMC Article
  3. Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Liao HK, et al. Dev Dyn, 2012 Feb. PMID 22275008, Free PMC Article
  4. Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. Karuppan SJ, et al. J Biol Chem, 2022 Feb. PMID 34958801, Free PMC Article
  5. Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy. Hinman MN, et al. Dis Model Mech, 2021 Jun 1. PMID 34125183, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results indicate the Appa-RFP and Aplp2 fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.
    Title: Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC158408

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
amyloid beta precursor like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123012.1 → NP_001116484.1  amyloid beta precursor like protein 2 precursor

    See identical proteins and their annotated locations for NP_001116484.1

    Status: PROVISIONAL

    Source sequence(s)
    BC160603
    UniProtKB/TrEMBL
    A2BID8, B1H1H1
    Related
    ENSDARP00000071593.5, ENSDART00000077125.6
    Conserved Domains (6) summary
    smart00006
    Location:31 → 195
    A4_EXTRA; amyloid A4
    pfam00014
    Location:314 → 366
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:38 → 138
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:710 → 760
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:140 → 195
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:371 → 553
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    44364530..44526895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214839.1 → XP_068070940.1  amyloid beta precursor like protein 2 isoform X5

  2. XM_021467714.2 → XP_021323389.1  amyloid beta precursor like protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PFK9
    Conserved Domains (3) summary
    smart00006
    Location:31 → 195
    A4_EXTRA; amyloid A4
    pfam10515
    Location:666 → 716
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:315 → 497
    APP_E2; E2 domain of amyloid precursor protein

  3. XM_021467713.2 → XP_021323388.1  amyloid beta precursor like protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PA77
    Conserved Domains (4) summary
    smart00006
    Location:31 → 195
    A4_EXTRA; amyloid A4
    pfam00014
    Location:314 → 366
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam10515
    Location:691 → 741
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:371 → 553
    APP_E2; E2 domain of amyloid precursor protein

  4. XM_021467712.2 → XP_021323387.1  amyloid beta precursor like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9P166
    Conserved Domains (4) summary
    smart00006
    Location:31 → 195
    A4_EXTRA; amyloid A4
    pfam00014
    Location:314 → 366
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam10515
    Location:703 → 753
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:371 → 553
    APP_E2; E2 domain of amyloid precursor protein

  5. XM_005159251.5 → XP_005159308.1  amyloid beta precursor like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Q4V0, A0A8M2B668
    Related
    ENSDARP00000147863.1, ENSDART00000189471.1
    Conserved Domains (6) summary
    smart00006
    Location:31 → 195
    A4_EXTRA; amyloid A4
    pfam00014
    Location:314 → 366
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:38 → 138
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:722 → 772
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:140 → 195
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:371 → 553
    APP_E2; E2 domain of amyloid precursor protein
Nucleotide Protein
Heading Accession and Version

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