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ier2a immediate early response 2a [ Danio rerio (zebrafish) ]

Gene ID: 797137, updated on 2-Nov-2024

Summary

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Official Symbol
ier2aprovided by ZNC
Official Full Name
immediate early response 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9126
See related
Ensembl:ENSDARG00000099195 AllianceGenome:ZFIN:ZDB-GENE-030131-9126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ier2; fb01b03; wu:fb01b03
Summary
Acts upstream of or within several processes, including Kupffer's vesicle development; cilium assembly; and determination of left/right symmetry. Located in nucleus. Is expressed in several structures, including axial chorda mesoderm; forebrain neural rod; midbrain hindbrain boundary; otic placode; and tail bud. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human IER2 (immediate early response 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ier2a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (33761549..33762730)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (33629936..33631114)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 29 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing a Neighboring gene calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a Neighboring gene alkB homolog 7 Neighboring gene general transcription factor IIF, polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toxicity assessment of atmospheric particulate matter in the Mediterranean and Black Seas open waters. Mesquita SR, et al. Sci Total Environ, 2016 Mar 1. PMID 26745302
  2. Toxic potential of organic constituents of submicron particulate matter (PM1) in an urban road site (Barcelona). Mesquita SR, et al. Environ Sci Pollut Res Int, 2017 Jun. PMID 28508335
  3. FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1. Hong SK, et al. Proc Natl Acad Sci U S A, 2009 Feb 17. PMID 19164561, Free PMC Article
  4. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Mesquita SR, et al. Environ Pollut, 2015 Nov. PMID 26298234
  5. Active nuclear transcriptome analysis reveals inflammasome-dependent mechanism for early neutrophil response to Mycobacterium marinum. Kenyon A, et al. Sci Rep, 2017 Jul 26. PMID 28747644, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Kupffer's vesicle development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within Kupffer's vesicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within convergent extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
immediate early response gene 2 protein
Names
immediate early response 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142583.3 → NP_001136055.2  immediate early response gene 2 protein

    Status: VALIDATED

    Source sequence(s)
    EH483632, EH510074, LO018483
    UniProtKB/Swiss-Prot
    B7SXM5
    UniProtKB/TrEMBL
    A0A0M3HEM8, A0A8M1NQN6
    Related
    ENSDARP00000135138.1, ENSDART00000169337.2
    Conserved Domains (1) summary
    pfam05760
    Location:1 → 97
    IER; Immediate early response protein (IER)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    33761549..33762730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7SXM5.1 GenPept UniProtKB/Swiss-Prot:B7SXM5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials