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tada2a transcriptional adaptor 2A [ Danio rerio (zebrafish) ]

Gene ID: 797303, updated on 11-Apr-2024

Summary

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Official Symbol
tada2aprovided by ZNC
Official Full Name
transcriptional adaptor 2Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-508
See related
Ensembl:ENSDARG00000031562 AllianceGenome:ZFIN:ZDB-GENE-060929-508
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tada2l; zgc:154057
Summary
Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to be involved in chromatin remodeling; positive regulation of histone acetylation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of histone acetylation. Predicted to be part of SAGA-type complex. Predicted to be active in nucleus. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See tada2a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (15786198..15819598)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (15850179..15883576)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch211-33e4.2 Neighboring gene uncharacterized LOC110437939 Neighboring gene dual specificity phosphatase 14 Neighboring gene synergin, gamma

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function. Manesia JK, et al. Stem Cells Dev, 2017 Apr 15. PMID 27958775, Free PMC Article
  2. Transcriptome analysis of Traf6 function in the innate immune response of zebrafish embryos. Stockhammer OW, et al. Mol Immunol, 2010 Nov-Dec. PMID 20851470
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC154057

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SAGA-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcriptional adapter 2-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077141.1 → NP_001070609.1  transcriptional adapter 2-alpha

    See identical proteins and their annotated locations for NP_001070609.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124525
    UniProtKB/TrEMBL
    Q08BW8
    Related
    ENSDARP00000085372.4, ENSDART00000090939.6
    Conserved Domains (4) summary
    COG5114
    Location:28 → 418
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    cd00167
    Location:75 → 117
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02335
    Location:15 → 64
    ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam04433
    Location:352 → 419
    SWIRM; SWIRM domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    15786198..15819598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157436.4 → XP_005157493.1  transcriptional adapter 2-alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M2B3J9, E7EZS5
    Related
    ENSDARP00000111548.1, ENSDART00000130670.4
    Conserved Domains (4) summary
    COG5114
    Location:28 → 442
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    cd00167
    Location:75 → 117
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02335
    Location:15 → 64
    ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam04433
    Location:376 → 443
    SWIRM; SWIRM domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394941.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    102127..144689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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