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ACBD4 acyl-CoA binding domain containing 4 [ Homo sapiens (human) ]

Gene ID: 79777, updated on 28-Oct-2024

Summary

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Official Symbol
ACBD4provided by HGNC
Official Full Name
acyl-CoA binding domain containing 4provided by HGNC
Primary source
HGNC:HGNC:23337
See related
Ensembl:ENSG00000181513 MIM:619968; AllianceGenome:HGNC:23337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HMFT0700
Summary
This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in liver (RPKM 7.3), duodenum (RPKM 7.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ACBD4 in Genome Data Viewer
Location:
17q21.31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45131597..45144176)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45985481..45998057)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43209986..43221543)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43138457-43139448 Neighboring gene N-myristoyltransferase 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:43168092-43168593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43175496-43175996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43175997-43176497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43180894-43181394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43184227-43184728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43189298-43190163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43190164-43191028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43191895-43192759 Neighboring gene phospholipase C delta 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43198136-43198673 Neighboring gene microRNA 6784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43220320-43221042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43221043-43221764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43222487-43223207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43224945-43225827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12277 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43226945-43227500 Neighboring gene HEXIM2 antisense RNA 1 Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43237877-43238492 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43238493-43239108 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43239109-43239724 Neighboring gene uncharacterized LOC105371795 Neighboring gene HEXIM P-TEFb complex subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Costello JL, et al. Cell Cycle, 2017 Jun 3. PMID 28463579, Free PMC Article
  2. Differential roles for ACBD4 and ACBD5 in peroxisome-ER interactions and lipid metabolism. Costello JL, et al. J Biol Chem, 2023 Aug. PMID 37414147, Free PMC Article
  3. Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study. Ho JE, et al. J Hypertens, 2011 Jan. PMID 21045733, Free PMC Article
  4. Genome-wide association study identifies eight loci associated with blood pressure. Newton-Cheh C, et al. Nat Genet, 2009 Jun. PMID 19430483, Free PMC Article
  5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. Yamada S, et al. Oncogene, 2004 Aug 5. PMID 15221005

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies eight loci associated with blood pressure.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13322, FLJ90623

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
acyl-CoA-binding domain-containing protein 4
Names
acyl-Coenzyme A binding domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135705.3 → NP_001129177.1  acyl-CoA-binding domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001129177.1

    Status: REVIEWED

    Source sequence(s)
    BC029164, BF514946, DC393065
    Consensus CDS
    CCDS42348.1
    UniProtKB/TrEMBL
    A0A0S2Z5Q0
    Related
    ENSP00000314440.8, ENST00000321854.13
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  2. NM_001135706.3 → NP_001129178.1  acyl-CoA-binding domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001129178.1

    Status: REVIEWED

    Source sequence(s)
    AK296167, BC041143
    Consensus CDS
    CCDS45710.1
    UniProtKB/TrEMBL
    A0A0S2Z5Y4, B4DJP3, B7ZAP4
    Related
    ENSP00000465484.1, ENST00000586346.5
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  3. NM_001135707.3 → NP_001129179.1  acyl-CoA-binding domain-containing protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001129179.1

    Status: REVIEWED

    Source sequence(s)
    AC142472, AK075104, BC041143, CN293965, DC393065
    Consensus CDS
    CCDS45711.1
    UniProtKB/Swiss-Prot
    D3DX64, Q8IUT1, Q8NC06, Q9H8Q4
    Related
    ENSP00000366154.3, ENST00000376955.8
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  4. NM_001321352.2 → NP_001308281.1  acyl-CoA-binding domain-containing protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    BC041143, DB128538
    Consensus CDS
    CCDS45710.1
    UniProtKB/TrEMBL
    A0A0S2Z5Y4, B4DJP3, B7ZAP4
    Related
    ENSP00000465610.1, ENST00000591859.5
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  5. NM_001321353.2 → NP_001308282.1  acyl-CoA-binding domain-containing protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC142472, BC041143, DB128538
    Consensus CDS
    CCDS45710.1
    UniProtKB/TrEMBL
    A0A0S2Z5Y4, B4DJP3, B7ZAP4
    Related
    ENSP00000405969.1, ENST00000431281.5
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  6. NM_001378111.1 → NP_001365040.1  acyl-CoA-binding domain-containing protein 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC142472
    UniProtKB/TrEMBL
    B4DJP3
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  7. NM_001378112.1 → NP_001365041.1  acyl-CoA-binding domain-containing protein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC142472

  8. NM_001411125.1 → NP_001398054.1  acyl-CoA-binding domain-containing protein 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC142472
    Consensus CDS
    CCDS92338.1
    UniProtKB/TrEMBL
    K7EM05

  9. NM_024722.4 → NP_078998.1  acyl-CoA-binding domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_078998.1

    Status: REVIEWED

    Source sequence(s)
    AK023384, BC041143, DC421936
    Consensus CDS
    CCDS42348.1
    UniProtKB/TrEMBL
    A0A0S2Z5Q0
    Related
    ENSP00000381367.2, ENST00000398322.7
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    45131597..45144176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436765.1 → XP_047292721.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  2. XM_017025092.3 → XP_016880581.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  3. XM_047436763.1 → XP_047292719.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  4. XM_017025084.2 → XP_016880573.1  acyl-CoA-binding domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    B4DJP3, B7ZAP4
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  5. XM_017025095.2 → XP_016880584.1  acyl-CoA-binding domain-containing protein 4 isoform X16

    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  6. XM_047436766.1 → XP_047292722.1  acyl-CoA-binding domain-containing protein 4 isoform X12

  7. XM_047436768.1 → XP_047292724.1  acyl-CoA-binding domain-containing protein 4 isoform X14

  8. XM_017025087.2 → XP_016880576.1  acyl-CoA-binding domain-containing protein 4 isoform X2

    UniProtKB/TrEMBL
    B4DJP3, B7ZAP4
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  9. XM_047436767.1 → XP_047292723.1  acyl-CoA-binding domain-containing protein 4 isoform X13

  10. XM_047436769.1 → XP_047292725.1  acyl-CoA-binding domain-containing protein 4 isoform X15

  11. XM_017025088.2 → XP_016880577.1  acyl-CoA-binding domain-containing protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z5Y4, B4DJP3, B7ZAP4
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  12. XM_017025097.2 → XP_016880586.1  acyl-CoA-binding domain-containing protein 4 isoform X18

    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  13. XM_017025090.2 → XP_016880579.1  acyl-CoA-binding domain-containing protein 4 isoform X8

  14. XM_017025096.2 → XP_016880585.1  acyl-CoA-binding domain-containing protein 4 isoform X17

  15. XM_017025089.3 → XP_016880578.1  acyl-CoA-binding domain-containing protein 4 isoform X4

  16. XM_047436761.1 → XP_047292717.1  acyl-CoA-binding domain-containing protein 4 isoform X6

  17. XM_006722085.3 → XP_006722148.1  acyl-CoA-binding domain-containing protein 4 isoform X9

    UniProtKB/TrEMBL
    A0A0S2Z5W7
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  18. XM_047436760.1 → XP_047292716.1  acyl-CoA-binding domain-containing protein 4 isoform X5

  19. XM_047436762.1 → XP_047292718.1  acyl-CoA-binding domain-containing protein 4 isoform X7

  20. XM_017025099.2 → XP_016880588.1  acyl-CoA-binding domain-containing protein 4 isoform X19

    UniProtKB/TrEMBL
    K7EM05
    Related
    ENSP00000466305.1, ENST00000592162.5
    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  21. XM_047436764.1 → XP_047292720.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  22. XM_017025093.2 → XP_016880582.1  acyl-CoA-binding domain-containing protein 4 isoform X11

    UniProtKB/TrEMBL
    B4DJP3

  23. XM_017025100.2 → XP_016880589.1  acyl-CoA-binding domain-containing protein 4 isoform X20

  24. XM_011525259.3 → XP_011523561.1  acyl-CoA-binding domain-containing protein 4 isoform X21

    Conserved Domains (2) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein
    cl00464
    Location:103 → 199
    URO-D_CIMS_like; The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...

  25. XM_017025101.3 → XP_016880590.1  acyl-CoA-binding domain-containing protein 4 isoform X22

  26. XM_011525261.3 → XP_011523563.1  acyl-CoA-binding domain-containing protein 4 isoform X23

    Conserved Domains (1) summary
    pfam00887
    Location:13 → 93
    ACBP; Acyl CoA binding protein

  27. XM_047436772.1 → XP_047292728.1  acyl-CoA-binding domain-containing protein 4 isoform X23

  28. XM_047436770.1 → XP_047292726.1  acyl-CoA-binding domain-containing protein 4 isoform X18

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    45985481..45998057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317246.1 → XP_054173221.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  2. XM_054317247.1 → XP_054173222.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  3. XM_054317243.1 → XP_054173218.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  4. XM_054317233.1 → XP_054173208.1  acyl-CoA-binding domain-containing protein 4 isoform X1

  5. XM_054317253.1 → XP_054173228.1  acyl-CoA-binding domain-containing protein 4 isoform X16

  6. XM_054317249.1 → XP_054173224.1  acyl-CoA-binding domain-containing protein 4 isoform X12

  7. XM_054317251.1 → XP_054173226.1  acyl-CoA-binding domain-containing protein 4 isoform X14

  8. XM_054317234.1 → XP_054173209.1  acyl-CoA-binding domain-containing protein 4 isoform X2

  9. XM_054317250.1 → XP_054173225.1  acyl-CoA-binding domain-containing protein 4 isoform X13

  10. XM_054317252.1 → XP_054173227.1  acyl-CoA-binding domain-containing protein 4 isoform X15

  11. XM_054317235.1 → XP_054173210.1  acyl-CoA-binding domain-containing protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A0S2Z5Y4

  12. XM_054317255.1 → XP_054173230.1  acyl-CoA-binding domain-containing protein 4 isoform X18

  13. XM_054317240.1 → XP_054173215.1  acyl-CoA-binding domain-containing protein 4 isoform X8

  14. XM_054317254.1 → XP_054173229.1  acyl-CoA-binding domain-containing protein 4 isoform X17

  15. XM_054317236.1 → XP_054173211.1  acyl-CoA-binding domain-containing protein 4 isoform X4

  16. XM_054317238.1 → XP_054173213.1  acyl-CoA-binding domain-containing protein 4 isoform X6

  17. XM_054317241.1 → XP_054173216.1  acyl-CoA-binding domain-containing protein 4 isoform X9

    UniProtKB/TrEMBL
    A0A0S2Z5W7

  18. XM_054317237.1 → XP_054173212.1  acyl-CoA-binding domain-containing protein 4 isoform X5

  19. XM_054317239.1 → XP_054173214.1  acyl-CoA-binding domain-containing protein 4 isoform X7

  20. XM_054317242.1 → XP_054173217.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  21. XM_054317257.1 → XP_054173232.1  acyl-CoA-binding domain-containing protein 4 isoform X19

    UniProtKB/TrEMBL
    K7EM05

  22. XM_054317244.1 → XP_054173219.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  23. XM_054317248.1 → XP_054173223.1  acyl-CoA-binding domain-containing protein 4 isoform X11

  24. XM_054317260.1 → XP_054173235.1  acyl-CoA-binding domain-containing protein 4 isoform X21

  25. XM_054317262.1 → XP_054173237.1  acyl-CoA-binding domain-containing protein 4 isoform X23

  26. XM_054317264.1 → XP_054173239.1  acyl-CoA-binding domain-containing protein 4 isoform X23

  27. XM_054317259.1 → XP_054173234.1  acyl-CoA-binding domain-containing protein 4 isoform X20

  28. XM_054317261.1 → XP_054173236.1  acyl-CoA-binding domain-containing protein 4 isoform X22

  29. XM_054317245.1 → XP_054173220.1  acyl-CoA-binding domain-containing protein 4 isoform X10

    UniProtKB/TrEMBL
    A0A0S2Z5Q0

  30. XM_054317256.1 → XP_054173231.1  acyl-CoA-binding domain-containing protein 4 isoform X18

  31. XM_054317258.1 → XP_054173233.1  acyl-CoA-binding domain-containing protein 4 isoform X19

    UniProtKB/TrEMBL
    K7EM05

  32. XM_054317263.1 → XP_054173238.1  acyl-CoA-binding domain-containing protein 4 isoform X23

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135704.1: Suppressed sequence

    Description
    NM_001135704.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NC06.2 GenPept UniProtKB/Swiss-Prot:Q8NC06

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