U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF665 zinc finger protein 665 [ Homo sapiens (human) ]

Gene ID: 79788, updated on 10-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF665provided by HGNC
Official Full Name
zinc finger protein 665provided by HGNC
Primary source
HGNC:HGNC:25885
See related
Ensembl:ENSG00000197497 AllianceGenome:HGNC:25885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP160L
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in ovary (RPKM 1.8), thyroid (RPKM 1.0) and 23 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF665 in Genome Data Viewer
Location:
19q13.42
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53162424..53193358, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56244690..56272858, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53665677..53696611, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 415 Neighboring gene zinc finger protein 347 Neighboring gene MPRA-validated peak3548 silencer Neighboring gene MPRA-validated peak3549 silencer Neighboring gene Sharpr-MPRA regulatory region 171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:53685451-53685967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11005 Neighboring gene zinc finger protein 480-like Neighboring gene zinc finger protein 415 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-wide association study to identify genetic determinants of severe asthma. Wan YI, et al. Thorax, 2012 Sep. PMID 22561531
  2. New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing. Basei FL, et al. Proteome Sci, 2015. PMID 25798074, Free PMC Article
  3. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study to identify genetic determinants of severe asthma.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ14345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 665

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353457.2 → NP_001340386.1  zinc finger protein 665 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Conserved Domains (3) summary
    COG5048
    Location:162 → 550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5 → 46
    KRAB; KRAB box

  2. NM_001353458.2 → NP_001340387.1  zinc finger protein 665 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Conserved Domains (4) summary
    COG5048
    Location:192 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320 → 340
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:37 → 76
    KRAB; KRAB box
    pfam13465
    Location:640 → 664
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001353459.2 → NP_001340388.1  zinc finger protein 665 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS46169.1
    UniProtKB/Swiss-Prot
    A8K5T8, Q9H7R5
    Conserved Domains (5) summary
    COG5048
    Location:164 → 552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:292 → 312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:654 → 676
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:612 → 636
    zf-H2C2_2; Zinc-finger double domain

  4. NM_024733.5 → NP_079009.3  zinc finger protein 665 isoform 3

    See identical proteins and their annotated locations for NP_079009.3

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS46169.1
    UniProtKB/Swiss-Prot
    A8K5T8, Q9H7R5
    Related
    ENSP00000379702.2, ENST00000396424.5
    Conserved Domains (5) summary
    COG5048
    Location:164 → 552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:292 → 312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:654 → 676
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:612 → 636
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53162424..53193358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439451.1 → XP_047295407.1  zinc finger protein 665 isoform X6

    UniProtKB/TrEMBL
    A0A3Q5AD24
    Related
    ENSP00000469154.1, ENST00000600412.1

  2. XM_047439450.1 → XP_047295406.1  zinc finger protein 665 isoform X6

    UniProtKB/TrEMBL
    A0A3Q5AD24

  3. XM_047439448.1 → XP_047295404.1  zinc finger protein 665 isoform X4

  4. XM_011527325.4 → XP_011525627.1  zinc finger protein 665 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:25 → 78
    KRAB; krueppel associated box
    COG5048
    Location:181 → 569
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:309 → 329
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:559 → 581
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:25 → 64
    KRAB; KRAB box
    pfam13465
    Location:321 → 345
    zf-H2C2_2; Zinc-finger double domain

  5. XM_047439449.1 → XP_047295405.1  zinc finger protein 665 isoform X5

  6. XM_047439446.1 → XP_047295402.1  zinc finger protein 665 isoform X2

    UniProtKB/Swiss-Prot
    A8K5T8, Q9H7R5

  7. XM_047439447.1 → XP_047295403.1  zinc finger protein 665 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56244690..56272858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322184.1 → XP_054178159.1  zinc finger protein 665 isoform X6

  2. XM_054322183.1 → XP_054178158.1  zinc finger protein 665 isoform X6

  3. XM_054322181.1 → XP_054178156.1  zinc finger protein 665 isoform X4

  4. XM_054322182.1 → XP_054178157.1  zinc finger protein 665 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H7R5.3 GenPept UniProtKB/Swiss-Prot:Q9H7R5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous