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TFPI2 tissue factor pathway inhibitor 2 [ Homo sapiens (human) ]

Gene ID: 7980, updated on 14-Nov-2024

Summary

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Official Symbol
TFPI2provided by HGNC
Official Full Name
tissue factor pathway inhibitor 2provided by HGNC
Primary source
HGNC:HGNC:11761
See related
Ensembl:ENSG00000105825 MIM:600033; AllianceGenome:HGNC:11761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP5; REF1; TFPI-2
Summary
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Biased expression in placenta (RPKM 566.0) and fat (RPKM 18.9) See more
Orthologs
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Genomic context

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See TFPI2 in Genome Data Viewer
Location:
7q21.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (93885396..93890753, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (95122034..95127402, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93514708..93520065, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 pseudogene 2 Neighboring gene uncharacterized LOC124901811 Neighboring gene TFPI2 divergent transcript Neighboring gene G protein subunit gamma transducin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tissue factor pathway inhibitor 2: Current understanding, challenges, and future perspectives.
    Title: Tissue factor pathway inhibitor 2: Current understanding, challenges, and future perspectives.
  2. Integrative analyses of RNA-seq and ChIP-seq Reveal MITF as a Target Gene of TFPI-2 in MDA231 Cells.
    Title: Integrative analyses of RNA-seq and ChIP-seq Reveal MITF as a Target Gene of TFPI-2 in MDA231 Cells.
  3. The role of tissue factor pathway inhibitor 2 in the coagulation and fibrinolysis system.
    Title: The role of tissue factor pathway inhibitor 2 in the coagulation and fibrinolysis system.
  4. HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
    Title: HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
  5. Exosomal miR-195 in hUC-MSCs alleviates hypoxia-induced damage of trophoblast cells through tissue factor pathway inhibitor 2.
    Title: Exosomal miR-195 in hUC-MSCs alleviates hypoxia-induced damage of trophoblast cells through tissue factor pathway inhibitor 2.
  6. m(6)A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2.
    Title: m(6)A RNA demethylase FTO promotes the growth, migration and invasion of pancreatic cancer cells through inhibiting TFPI-2.
  7. MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2.
    Title: MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2.
  8. Tissue Factor Pathway Inhibitor 2: A Novel Biomarker for Predicting Asymptomatic Venous Thromboembolism in Patients with Epithelial Ovarian Cancer.
    Title: Tissue Factor Pathway Inhibitor 2: A Novel Biomarker for Predicting Asymptomatic Venous Thromboembolism in Patients with Epithelial Ovarian Cancer.
  9. MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.
    Title: MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium.
  10. The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer.
    Title: The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (125)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of tissue factor pathway inhibitor 2 (TFPI2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of tissue factor pathway inhibitor 2 (TFPI2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix structural constituent TAS
Traceable Author Statement
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix TAS
Traceable Author Statement
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tissue factor pathway inhibitor 2
Names
placental protein 5
retinal pigment epithelium cell factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032914.1 RefSeqGene

    Range
    5239..10596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_647

mRNA and Protein(s)

  1. NM_001271003.2 → NP_001257932.1  tissue factor pathway inhibitor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001257932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC002076, AK092499, AK129833
    UniProtKB/TrEMBL
    A0A3B3IS67
    Conserved Domains (2) summary
    cd00109
    Location:26 → 75
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:146 → 193
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  2. NM_001271004.2 → NP_001257933.1  tissue factor pathway inhibitor 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001257933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC002076, AK129833, DA831865, DA833200
    UniProtKB/TrEMBL
    A0A3B3IRW1
    Conserved Domains (2) summary
    cd00109
    Location:34 → 86
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:95 → 149
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

  3. NM_006528.4 → NP_006519.1  tissue factor pathway inhibitor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006519.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC002076, AK129833
    Consensus CDS
    CCDS5632.1
    UniProtKB/Swiss-Prot
    P48307, Q66ME8, Q8NAK6, Q9UC86
    UniProtKB/TrEMBL
    A0A3B3IS67
    Related
    ENSP00000222543.5, ENST00000222543.11
    Conserved Domains (2) summary
    cd00109
    Location:34 → 86
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam00014
    Location:157 → 204
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    93885396..93890753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    95122034..95127402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48307.1 GenPept UniProtKB/Swiss-Prot:P48307

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