gga1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gga1provided by ZNC
Official Full Name: golgi-associated, gamma adaptin ear containing, ARF binding protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040822-13
See related: Ensembl:ENSDARG00000038537 AllianceGenome:ZFIN:ZDB-GENE-040822-13
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb33h10; im:6912200; wu:fb33h10; zgc:101044
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport and protein localization to cell surface. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus and early endosome membrane. Predicted to be active in trans-Golgi network. Orthologous to human GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (22119758..22145934, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (20059536..20085712, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb33h10.x1 (e-PCR)
- UniSTS:203127

fd17g05.y1 (e-PCR)
- UniSTS:195229

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADP-ribosylation factor-binding protein GGA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004000.2 → NP_001004000.2 ADP-ribosylation factor-binding protein GGA1

Status: VALIDATED

Source sequence(s)

BC155255, CR626864, CT736351, EB911367, EH435716

UniProtKB/TrEMBL

A0A2R8QEJ6, A0A8M1N1X2, A9JT96

Related

ENSDARP00000150330.1, ENSDART00000181700.1

Conserved Domains (3) summary

smart00809
Location:513 → 627

Alpha_adaptinC2; Adaptin C-terminal domain

cd03567
Location:9 → 147

VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...

cd14239
Location:210 → 298

GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2