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ttyh3b tweety family member 3b [ Danio rerio (zebrafish) ]

Gene ID: 798421, updated on 2-Nov-2024

Summary

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Official Symbol
ttyh3bprovided by ZNC
Official Full Name
tweety family member 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-051120-105
See related
Ensembl:ENSDARG00000007678 AllianceGenome:ZFIN:ZDB-GENE-051120-105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ttyh3; fj56f11; wu:fj56f11; zgc:123242
Summary
Predicted to enable calcium ion binding activity; intracellularly calcium-gated chloride channel activity; and volume-sensitive chloride channel activity. Predicted to be involved in L-glutamate transmembrane transport. Predicted to act upstream of or within chloride transport and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of chloride channel complex. Predicted to be active in plasma membrane. Orthologous to human TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See ttyh3b in Genome Data Viewer
Location:
chromosome: 1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (11781544..11850368, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (11098845..11163563, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 12b, tandem duplicate 1 Neighboring gene zmp:0000001069 Neighboring gene IQ motif containing E Neighboring gene uncharacterized LOC137495029 Neighboring gene sorting nexin 8b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Hogl S, et al. Proteomics, 2013 May. PMID 23457027
  2. Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Nittoli V, et al. Gene X, 2019 Jun. PMID 31193955, Free PMC Article
  3. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC123242

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables volume-sensitive chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables volume-sensitive chloride channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein tweety homolog 3
Names
tweety homolog 3b
volume-regulated anion channel subunit ttyh3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037387.3 → NP_001032464.2  protein tweety homolog 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX569778
    Related
    ENSDARP00000036553.7, ENSDART00000033361.8

  2. NM_001431093.1 → NP_001418022.1  protein tweety homolog 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX569778

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    11781544..11850368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32LT7.1 GenPept UniProtKB/Swiss-Prot:Q32LT7

Gene LinkOut

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