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ZNF613 zinc finger protein 613 [ Homo sapiens (human) ]

Gene ID: 79898, updated on 3-Nov-2024

Summary

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Official Symbol
ZNF613provided by HGNC
Official Full Name
zinc finger protein 613provided by HGNC
Primary source
HGNC:HGNC:25827
See related
Ensembl:ENSG00000176024 AllianceGenome:HGNC:25827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in prostate (RPKM 6.4), placenta (RPKM 2.1) and 22 other tissues See more
Orthologs
all
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Genomic context

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See ZNF613 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51927472..51946621)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55014667..55033819)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52430725..52449874)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF649 antisense RNA 1 Neighboring gene zinc finger protein 649 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:52404806-52405052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:52406403-52406948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52408039-52408583 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52408912-52409536 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:52410420-52411095 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:52411096-52411770 Neighboring gene zinc finger protein 41 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52429745-52430508 Neighboring gene ZNF350 antisense RNA 1 Neighboring gene zinc finger protein 350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:52489558-52490433 Neighboring gene zinc finger protein 615 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15032

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomic Regions Associated With Gestation Length Detected Using Whole-Genome Sequence Data Differ Between Dairy and Beef Cattle. Purfield DC, et al. Front Genet, 2019. PMID 31749838, Free PMC Article
  2. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216
  3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13590

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 613

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031721.4 → NP_001026891.2  zinc finger protein 613 isoform 1

    See identical proteins and their annotated locations for NP_001026891.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011460, AK027565, BC057776, CA427456
    Consensus CDS
    CCDS33089.1
    UniProtKB/Swiss-Prot
    Q6PF04, Q96SS9
    Related
    ENSP00000293471.5, ENST00000293471.11
    Conserved Domains (6) summary
    smart00349
    Location:8 → 67
    KRAB; krueppel associated box
    COG5048
    Location:176 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:374 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:484 → 506
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:414 → 439
    zf-H2C2_2; Zinc-finger double domain

  2. NM_024840.4 → NP_079116.2  zinc finger protein 613 isoform 2

    See identical proteins and their annotated locations for NP_079116.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC011460, AK027565, CA427456
    Consensus CDS
    CCDS12844.1
    UniProtKB/Swiss-Prot
    Q6PF04
    Related
    ENSP00000375671.3, ENST00000391794.8
    Conserved Domains (5) summary
    smart00349
    Location:1 → 31
    KRAB; krueppel associated box
    COG5048
    Location:140 → 495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:338 → 358
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:448 → 470
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:378 → 403
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51927472..51946621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55014667..55033819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PF04.2 GenPept UniProtKB/Swiss-Prot:Q6PF04

Gene LinkOut

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