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DGLUCY D-glutamate cyclase [ Homo sapiens (human) ]

Gene ID: 80017, updated on 10-Dec-2024

Summary

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Official Symbol
DGLUCYprovided by HGNC
Official Full Name
D-glutamate cyclaseprovided by HGNC
Primary source
HGNC:HGNC:20498
See related
Ensembl:ENSG00000133943 MIM:620716; AllianceGenome:HGNC:20498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf159
Summary
Predicted to enable D-glutamate cyclase activity. Predicted to be involved in glutamate metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in heart (RPKM 27.3), kidney (RPKM 11.9) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See DGLUCY in Genome Data Viewer
Location:
14q32.11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (91060333..91225632)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (85285776..85451130)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (91526677..91691976)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene ReSE screen-validated silencer GRCh37_chr14:91260136-91260298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6013 Neighboring gene MPRA-validated peak2229 silencer Neighboring gene ribosomal protein S18 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6014 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:91311907-91312408 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:91312409-91312908 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:91315826-91316592 Neighboring gene long intergenic non-protein coding RNA 2321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8883 Neighboring gene ribosomal protein S6 kinase A5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:91526715-91527295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8892 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:91579864-91580776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:91582717-91583218 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:91585689-91586888 Neighboring gene RNA, U7 small nuclear 30 pseudogene Neighboring gene Sharpr-MPRA regulatory region 15407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8894 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:91619068-91619346 Neighboring gene Sharpr-MPRA regulatory region 3148 Neighboring gene small nucleolar RNA, H/ACA box 11B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:91710745-91711246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:91719939-91720470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:91720471-91721002 Neighboring gene CRISPRi-validated cis-regulatory element chr14.1904 Neighboring gene Sharpr-MPRA regulatory region 4292 Neighboring gene CRISPRi-validated cis-regulatory element chr14.1906 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:91749514-91749720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6023 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:91772467-91773300 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:91771631-91772466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8902 Neighboring gene G protein-coupled receptor 68 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8903 Neighboring gene coiled-coil domain containing 88C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8906 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:91818809-91819780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:91821242-91821752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:91826971-91827470 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:91826469-91826970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8910 Neighboring gene uncharacterized LOC107984673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:91838097-91838709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8911

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Identification of a Highly Conserved Hypothetical Protein TON_0340 as a Probable Manganese-Dependent Phosphatase. Sohn YS, et al. PLoS One, 2016. PMID 27907125, Free PMC Article
  2. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Cheng J, et al. Science, 2005 May 20. PMID 15790807
  3. (D)-Glutamate is metabolized in the heart mitochondria. Ariyoshi M, et al. Sci Rep, 2017 Mar 7. PMID 28266638, Free PMC Article
  4. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Hou P, et al. Cancer Res, 2017 Aug 15. PMID 28625976, Free PMC Article
  5. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20950, FLJ39943, FLJ39975, DKFZp686I02128

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D-glutamate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-glutamate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
D-glutamate cyclase, mitochondrial
Names
UPF0317 protein C14orf159, mitochondrial
NP_001095836.1
NP_001095837.1
NP_001095838.1
NP_001095839.1
NP_001273399.1
NP_001273400.1
NP_001273401.1
NP_001273402.1
NP_001345239.1
NP_001345240.1
NP_001345241.1
NP_079228.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102366.3 → NP_001095836.1  D-glutamate cyclase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001095836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (a). Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AL121784, AL135818, AL602721, BC065558, BX642394, DR003467
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    B3KUI7, Q7Z3D6, Q86SW3, Q86SX8, Q86SX9, Q86T08, Q86TV5, Q96GW5, Q9H7G0, Q9H8Y9, Q9H9W6
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Related
    ENSP00000428974.1, ENST00000523816.5
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298 → 608
    DUF4392; Domain of unknown function (DUF4392)

  2. NM_001102367.2 → NP_001095837.1  D-glutamate cyclase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001095837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AL121784, BC010614, BX642394, DB258432, DR003467
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    B3KUI7, Q7Z3D6, Q86SW3, Q86SX8, Q86SX9, Q86T08, Q86TV5, Q96GW5, Q9H7G0, Q9H8Y9, Q9H9W6
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Related
    ENSP00000427953.1, ENST00000522322.5
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298 → 608
    DUF4392; Domain of unknown function (DUF4392)

  3. NM_001102368.3 → NP_001095838.1  D-glutamate cyclase, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001095838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is longer than isoform a. Variants 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AB210031, AL135818, BC065558, BX642394, DA296867, DR003467
    Consensus CDS
    CCDS41979.1
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Related
    ENSP00000256324.9, ENST00000256324.15
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 260
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303 → 613
    DUF4392; Domain of unknown function (DUF4392)

  4. NM_001102369.3 → NP_001095839.1  D-glutamate cyclase, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_001095839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate in-frame splice site, and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK023200, AL121784, AL135818, BC065558, BX642394, DA641301, DR003467
    Consensus CDS
    CCDS45150.1
    UniProtKB/TrEMBL
    B3KVU6
    Related
    ENSP00000429453.1, ENST00000520328.5
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 242
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:286 → 556
    DUF4392; Domain of unknown function (DUF4392)

  5. NM_001286470.2 → NP_001273399.1  D-glutamate cyclase, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_001273399.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is longer than isoform a. Variants 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AA192653, AK123532, AL121784, AL135818, AL602721, BC065558, BX161393, DR003467
    Consensus CDS
    CCDS41979.1
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Related
    ENSP00000428263.1, ENST00000518868.5
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 260
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303 → 613
    DUF4392; Domain of unknown function (DUF4392)

  6. NM_001286471.1 → NP_001273400.1  D-glutamate cyclase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001273400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AA192653, AL121784, AY358516, BC065558, BX161393, DR003467
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    B3KUI7, Q7Z3D6, Q86SW3, Q86SX8, Q86SX9, Q86T08, Q86TV5, Q96GW5, Q9H7G0, Q9H8Y9, Q9H9W6
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Related
    ENSP00000429655.1, ENST00000523771.5
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298 → 608
    DUF4392; Domain of unknown function (DUF4392)

  7. NM_001286472.2 → NP_001273401.1  D-glutamate cyclase, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_001273401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, uses an alternate in-frame splice site, and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AL135818, BX247989, DA296867, DR003467
    Consensus CDS
    CCDS66693.1
    UniProtKB/TrEMBL
    B3KVU6
    Related
    ENSP00000430137.1, ENST00000521077.6
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 259
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303 → 573
    DUF4392; Domain of unknown function (DUF4392)

  8. NM_001286473.2 → NP_001273402.1  D-glutamate cyclase, mitochondrial isoform e

    See identical proteins and their annotated locations for NP_001273402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, and lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AI825879, BC009182, DA296867
    Consensus CDS
    CCDS73677.1
    UniProtKB/Swiss-Prot
    Q7Z3D6
    Related
    ENSP00000429098.1, ENST00000518665.6
    Conserved Domains (1) summary
    cl01790
    Location:12 → 77
    DUF1445; Protein of unknown function (DUF1445)

  9. NM_001358310.2 → NP_001345239.1  D-glutamate cyclase, mitochondrial isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL135818
    Consensus CDS
    CCDS41979.1
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 260
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303 → 613
    DUF4392; Domain of unknown function (DUF4392)

  10. NM_001358311.2 → NP_001345240.1  D-glutamate cyclase, mitochondrial isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL135818
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    B3KUI7, Q7Z3D6, Q86SW3, Q86SX8, Q86SX9, Q86T08, Q86TV5, Q96GW5, Q9H7G0, Q9H8Y9, Q9H9W6
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298 → 608
    DUF4392; Domain of unknown function (DUF4392)

  11. NM_001358312.2 → NP_001345241.1  D-glutamate cyclase, mitochondrial isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AL121784, AL135818
    Consensus CDS
    CCDS41979.1
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 260
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:303 → 613
    DUF4392; Domain of unknown function (DUF4392)

  12. NM_024952.8 → NP_079228.4  D-glutamate cyclase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_079228.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 7 encode the same isoform (a).
    Source sequence(s)
    AK022564, AL121784, AL135818, AL602721, BX642394, DR003467
    Consensus CDS
    CCDS32141.1
    UniProtKB/Swiss-Prot
    B3KUI7, Q7Z3D6, Q86SW3, Q86SX8, Q86SX9, Q86T08, Q86TV5, Q96GW5, Q9H7G0, Q9H8Y9, Q9H9W6
    UniProtKB/TrEMBL
    B3KVU6, Q6IA66
    Related
    ENSP00000404343.2, ENST00000428926.6
    Conserved Domains (2) summary
    pfam07286
    Location:118 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:298 → 608
    DUF4392; Domain of unknown function (DUF4392)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    91060333..91225632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    85285776..85451130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z3D6.2 GenPept UniProtKB/Swiss-Prot:Q7Z3D6

Gene LinkOut

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