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ARL14 ARF like GTPase 14 [ Homo sapiens (human) ]

Gene ID: 80117, updated on 27-Nov-2024

Summary

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Official Symbol
ARL14provided by HGNC
Official Full Name
ARF like GTPase 14provided by HGNC
Primary source
HGNC:HGNC:22974
See related
Ensembl:ENSG00000179674 MIM:614439; AllianceGenome:HGNC:22974
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARF7
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to be located in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See ARL14 in Genome Data Viewer
Location:
3q25.33
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (160677160..160678448)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (163451739..163453027)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (160394948..160396236)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene keratin 8 pseudogene 12 Neighboring gene ribosomal protein L6 pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20760 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20761 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:160394435-160395634 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14858 Neighboring gene PPM1L divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations. Yang F, et al. J Biol Chem, 2020 Dec 4. PMID 32972971, Free PMC Article
  2. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Paul P, et al. Cell, 2011 Apr 15. PMID 21458045
  3. Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation. Senapati S, et al. Pharmacogenet Genomics, 2014 Apr. PMID 24583629
  4. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. Hirschfield GM, et al. N Engl J Med, 2009 Jun 11. PMID 19458352, Free PMC Article
  5. Human RAS superfamily proteins and related GTPases. Colicelli J. Sci STKE, 2004 Sep 7. PMID 15367757, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations.
    Title: The amphipathic helices of Arfrp1 and Arl14 are sufficient to determine subcellular localizations.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.
EBI GWAS Catalog
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ22595

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 14
Names
ADP ribosylation factor like GTPase 14
ADP-ribosylation factor 7
ADP-ribosylation factor-like 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025047.3 → NP_079323.1  ADP-ribosylation factor-like protein 14

    See identical proteins and their annotated locations for NP_079323.1

    Status: VALIDATED

    Source sequence(s)
    BC034354, BM760777
    Consensus CDS
    CCDS3192.1
    UniProtKB/Swiss-Prot
    Q8N4G2, Q9H655
    Related
    ENSP00000323847.2, ENST00000320767.4
    Conserved Domains (2) summary
    cd04156
    Location:15 → 174
    ARLTS1; Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11)
    smart00178
    Location:1 → 175
    SAR; Sar1p-like members of the Ras-family of small GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    160677160..160678448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    163451739..163453027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N4G2.2 GenPept UniProtKB/Swiss-Prot:Q8N4G2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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