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MAP3K19 mitogen-activated protein kinase kinase kinase 19 [ Homo sapiens (human) ]

Gene ID: 80122, updated on 27-Dec-2024

Summary

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Official Symbol
MAP3K19provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 19provided by HGNC
Primary source
HGNC:HGNC:26249
See related
Ensembl:ENSG00000176601 AllianceGenome:HGNC:26249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCK; YSK4
Summary
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in MAPK cascade. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis (RPKM 2.7), lung (RPKM 0.8) and 1 other tissue See more
Orthologs
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Genomic context

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See MAP3K19 in Genome Data Viewer
Location:
2q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (134964491..135047447, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (135404909..135487908, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135722061..135805017, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene CCNT2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:135675361-135676034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16569 Neighboring gene cyclin T2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135732781-135733282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135733283-135733782 Neighboring gene MPRA-validated peak3873 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16570 Neighboring gene small nucleolar RNA U13 Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene HNF4 motif-containing MPRA enhancer 203 Neighboring gene small nucleolar RNA, H/ACA box 40B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells. Hoang VT, et al. J Biol Chem, 2020 Jun 19. PMID 32358059, Free PMC Article
  2. MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction. Boehme SA, et al. PLoS One, 2016. PMID 27935962, Free PMC Article
  3. MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis. Boehme SA, et al. PLoS One, 2016. PMID 27144281, Free PMC Article
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
  5. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. Silva LE, et al. J Proteome Res, 2019 Oct 4. PMID 31478661

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells.
    Title: The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells.
  2. Mitogen-activated protein kinase kinase kinase 19 (MAP3K19) is overexpressed in the lungs of chronic obstructive pulmonary disease (COPD) patients.
    Title: MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23074

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 19
Names
SPS1/STE20-related protein kinase YSK4
YSK4 Sps1/Ste20-related kinase homolog
regulated in COPD kinase
regulated in COPD, protein kinase
yeast Sps1/Ste20-related kinase 4
NP_001018054.1
NP_001018056.1
NP_001018057.1
NP_001269812.1
NP_001308106.1
NP_001387367.1
NP_079328.3
XP_011510193.1
XP_011510198.1
XP_011510199.1
XP_016860493.1
XP_016860494.1
XP_016860495.1
XP_016860496.1
XP_047301873.1
XP_054200002.1
XP_054200003.1
XP_054200004.1
XP_054200005.1
XP_054200006.1
XP_054200007.1
XP_054200008.1
XP_054200009.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018044.3 → NP_001018054.1  mitogen-activated protein kinase kinase kinase 19 isoform 3

    See identical proteins and their annotated locations for NP_001018054.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574902, BU676900
    Consensus CDS
    CCDS63020.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000351140.4, ENST00000358371.9
    Conserved Domains (2) summary
    smart00220
    Location:948 → 1211
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:946 → 1211
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

  2. NM_001018046.3 → NP_001018056.1  mitogen-activated protein kinase kinase kinase 19 isoform 2

    See identical proteins and their annotated locations for NP_001018056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574904, BU676900
    Consensus CDS
    CCDS33293.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000365004.3, ENST00000375844.7
    Conserved Domains (2) summary
    smart00220
    Location:243 → 506
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:241 → 506
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

  3. NM_001018047.3 → NP_001018057.1  mitogen-activated protein kinase kinase kinase 19 isoform 4

    See identical proteins and their annotated locations for NP_001018057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, and uses two alternate splice sites that result in the loss of an in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AY574905, BU676900
    Consensus CDS
    CCDS63022.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000376650.3, ENST00000392918.7
    Conserved Domains (2) summary
    smart00220
    Location:227 → 458
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:246 → 458
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001282883.2 → NP_001269812.1  mitogen-activated protein kinase kinase kinase 19 isoform 5

    See identical proteins and their annotated locations for NP_001269812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons that result in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC016725, AC020602, BC144555, BU676900
    Consensus CDS
    CCDS63021.1
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENSP00000376649.3, ENST00000392917.8
    Conserved Domains (2) summary
    smart00220
    Location:206 → 456
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:206 → 456
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

  5. NM_001321177.2 → NP_001308106.1  mitogen-activated protein kinase kinase kinase 19 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016725, AK122935, BC034417, BC137277
    UniProtKB/Swiss-Prot
    Q56UN5
    Related
    ENST00000638025.2
    Conserved Domains (1) summary
    cl21453
    Location:1076 → 1092
    PKc_like; Protein Kinases, catalytic domain

  6. NM_001400438.1 → NP_001387367.1  mitogen-activated protein kinase kinase kinase 19 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016725, AC020602
    Consensus CDS
    CCDS2176.2
    UniProtKB/Swiss-Prot
    B2RP57, B7ZMH9, E2QRE3, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q56UN5, Q8N4E9, Q9H5T2

  7. NM_025052.5 → NP_079328.3  mitogen-activated protein kinase kinase kinase 19 isoform 1

    See identical proteins and their annotated locations for NP_079328.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC016725, AC020602
    Consensus CDS
    CCDS2176.2
    UniProtKB/Swiss-Prot
    B2RP57, B7ZMH9, E2QRE3, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q56UN5, Q8N4E9, Q9H5T2
    Related
    ENSP00000376647.2, ENST00000392915.7
    Conserved Domains (2) summary
    smart00220
    Location:1061 → 1324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:1059 → 1324
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    134964491..135047447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005005.3 → XP_016860494.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:1033 → 1296
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:1031 → 1296
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

  2. XM_017005004.3 → XP_016860493.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:1033 → 1296
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:1031 → 1296
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

  3. XM_017005006.3 → XP_016860495.1  mitogen-activated protein kinase kinase kinase 19 isoform X4

  4. XM_011511891.3 → XP_011510193.1  mitogen-activated protein kinase kinase kinase 19 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:1078 → 1341
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:1076 → 1341
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

  5. XM_011511896.4 → XP_011510198.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

    See identical proteins and their annotated locations for XP_011510198.1

    Conserved Domains (2) summary
    smart00220
    Location:966 → 1229
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:964 → 1229
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

  6. XM_011511897.4 → XP_011510199.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

    See identical proteins and their annotated locations for XP_011510199.1

    Conserved Domains (2) summary
    smart00220
    Location:966 → 1229
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06631
    Location:964 → 1229
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4

  7. XM_017005007.2 → XP_016860496.1  mitogen-activated protein kinase kinase kinase 19 isoform X6

    UniProtKB/TrEMBL
    A0A1B0GTF4

  8. XM_047445917.1 → XP_047301873.1  mitogen-activated protein kinase kinase kinase 19 isoform X5

    UniProtKB/TrEMBL
    A0A1B0GTF4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    135404909..135487908 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344029.1 → XP_054200004.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

  2. XM_054344028.1 → XP_054200003.1  mitogen-activated protein kinase kinase kinase 19 isoform X2

  3. XM_054344032.1 → XP_054200007.1  mitogen-activated protein kinase kinase kinase 19 isoform X4

  4. XM_054344027.1 → XP_054200002.1  mitogen-activated protein kinase kinase kinase 19 isoform X1

  5. XM_054344030.1 → XP_054200005.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

  6. XM_054344031.1 → XP_054200006.1  mitogen-activated protein kinase kinase kinase 19 isoform X3

  7. XM_054344034.1 → XP_054200009.1  mitogen-activated protein kinase kinase kinase 19 isoform X6

    UniProtKB/TrEMBL
    A0A1B0GTF4

  8. XM_054344033.1 → XP_054200008.1  mitogen-activated protein kinase kinase kinase 19 isoform X5

    UniProtKB/TrEMBL
    A0A1B0GTF4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001018043.1: Suppressed sequence

    Description
    NM_001018043.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

  2. NM_001018045.1: Suppressed sequence

    Description
    NM_001018045.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q56UN5.1 GenPept UniProtKB/Swiss-Prot:Q56UN5

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