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N4bp1 NEDD4 binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 80750, updated on 17-Aug-2024

Summary

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Official Symbol
N4bp1provided by MGI
Official Full Name
NEDD4 binding protein 1provided by MGI
Primary source
MGI:MGI:2136825
See related
Ensembl:ENSMUSG00000031652 AllianceGenome:MGI:2136825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mRNA binding activity; ribonuclease activity; and ubiquitin binding activity. Involved in cellular response to UV; negative regulation of macromolecule metabolic process; and regulation of innate immune response. Located in PML body; cytosol; and nucleolus. Orthologous to human N4BP1 (NEDD4 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in stomach adult (RPKM 8.2), duodenum adult (RPKM 8.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C3; 8 42.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (87567764..87612489, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (86841136..86885296, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene siah E3 ubiquitin protein ligase 1A Neighboring gene STARR-seq mESC enhancer starr_22187 Neighboring gene predicted gene 10638 Neighboring gene STARR-seq mESC enhancer starr_22189 Neighboring gene predicted gene, 39215 Neighboring gene predicted gene, 33877 Neighboring gene STARR-positive B cell enhancer ABC_E11393 Neighboring gene STARR-seq mESC enhancer starr_22192 Neighboring gene STARR-seq mESC enhancer starr_22193 Neighboring gene ferritin heavy chain, pseudogene 3 Neighboring gene predicted gene, 33391

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration. Gou C, et al. Cell Death Dis, 2021 May 14. PMID 33990547, Free PMC Article
  2. Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage. Bracken CP, et al. Nucleic Acids Res, 2011 Jul. PMID 21427086, Free PMC Article
  3. N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization. Shi H, et al. Nat Commun, 2021 Mar 2. PMID 33654074, Free PMC Article
  4. N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies. Sharma P, et al. J Cell Sci, 2010 Apr 15. PMID 20233849, Free PMC Article
  5. Integration of innate immune signalling by caspase-8 cleavage of N4BP1. Gitlin AD, et al. Nature, 2020 Nov. PMID 32971525

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N4BP1 coordinates ubiquitin-dependent crosstalk within the IkappaB kinase family to limit Toll-like receptor signaling and inflammation.
    Title: N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation.
  2. N4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development.
    Title: N4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development.
  3. The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration.
    Title: The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration.
  4. N4BP1 negatively regulates NF-kappaB by binding and inhibiting NEMO oligomerization.
    Title: N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization.
  5. Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
    Title: Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
  6. N4BP1 can be conjugated with SUMO1 and that this abrogates N4BP1 ubiquitylation.
    Title: N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies.
  7. May have a role in regulating tumor progression and the response of cancer cells to chemotherapy.
    Title: The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7607

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA nuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NEDD4-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030563.2 → NP_085040.2  NEDD4-binding protein 1

    See identical proteins and their annotated locations for NP_085040.2

    Status: VALIDATED

    Source sequence(s)
    AA444325, AK147522, BC089324, BM951093, CJ134294, CX122841, CX240926
    Consensus CDS
    CCDS52625.1
    UniProtKB/Swiss-Prot
    Q3TCI4, Q3UH87, Q3UY69, Q6A037
    Related
    ENSMUSP00000034074.8, ENSMUST00000034074.8
    Conserved Domains (1) summary
    pfam11977
    Location:614 → 767
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    87567764..87612489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531517.4 → XP_006531580.1  NEDD4-binding protein 1 isoform X3

  2. XM_006531516.4 → XP_006531579.1  NEDD4-binding protein 1 isoform X1

    Conserved Domains (1) summary
    cl20439
    Location:628 → 691
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

  3. XM_036154392.1 → XP_036010285.1  NEDD4-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q5EBQ4
    Conserved Domains (2) summary
    cd18728
    Location:532 → 658
    PIN_N4BP1-like; PRORP-like PIN domain of NEDD4 binding protein 1 and related proteins
    cl00098
    Location:1 → 56
    KH-I; K homology (KH) RNA-binding domain, type I

  4. XM_036154391.1 → XP_036010284.1  NEDD4-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q5EBQ4
    Conserved Domains (2) summary
    cd18728
    Location:532 → 658
    PIN_N4BP1-like; PRORP-like PIN domain of NEDD4 binding protein 1 and related proteins
    cl00098
    Location:1 → 56
    KH-I; K homology (KH) RNA-binding domain, type I

  5. XM_036154393.1 → XP_036010286.1  NEDD4-binding protein 1 isoform X4

    Conserved Domains (1) summary
    cl00098
    Location:1 → 56
    KH-I; K homology (KH) RNA-binding domain, type I

RNA

  1. XR_004934903.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A037.2 GenPept UniProtKB/Swiss-Prot:Q6A037

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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